Uridine, 2′-deoxy-5-ethynyl- Cas: 61135-33-9
| Umubare wa Cataloge | XD90589 |
| izina RY'IGICURUZWA | Uridine, 2'-deoxy-5-ethynyl- |
| URUBANZA | 61135-33-9 |
| Inzira ya molekulari | C11H12N2O5 |
| Uburemere bwa molekile | 252.23 |
| Ibisobanuro birambuye | -20 ° C. |
| Amategeko agenga ibiciro | 29349990 |
Kugaragaza ibicuruzwa
| Kugaragara | Umweru kuri Orange kugeza icyatsi kibisi kuri kristu |
| Suzuma | ≥99% |
Ubu bushakashatsi bwakozwe kugira ngo hakorwe ubushakashatsi ku ngaruka zikwirakwizwa na soya peptide y’imboga ku ngirabuzimafatizo zikuze (ASCs) iyo serumu idahari hamwe n’uburyo bushoboka bwo gukora.Ikwirakwizwa rya adipose tissue yumuntu ikomoka kuri mesenchymal stem selile (ADSCs) hamwe ningirangingo ziva mumaraso ya Mesenchymal stem selile (CB-MSCs) zavuwe na soya peptide wasangaga ziyongera cyane kuri 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide na Kanda-iT 5-ethynyl-2'-deoxyuridine itemba cytometrie.Byongeye kandi, peptide ya soya yatumye fosifora yintambwe ya pAP / 42 MAPK (ERK), inyamaswa z’inyamabere zibasira rapamycine (mTOR), p70 S6 kinase, S6 ribosomal proteine (S6RP) hamwe na eukaryotic yo gutangiza 4E (eIF4E) muri ADSCs.Byongeye kandi, isesengura ryinshi ryakozwe na cytokine ryerekanye ko umusaruro wo guhindura ibintu bikura-beta1 (TGF-β1), imikurire yimitsi iva mu mitsi hamwe na interleukin-6 byiyongereye cyane mugusubiza imiti ya peptide ya soya muri ADSCs na CB-MSCs.Mu buryo nk'ubwo, soya peptide iterwa na fosifora yinzira ya ERK / mTOR / S6RP / eIF4E yarahagaritswe hasubijwe kwitegura hamwe na PD98059, inzitizi yihariye ya ERK.Byongeye kandi, kubuza TGF-β1 binyuze muri PD98059 no kugabanuka gukurikiranye kwa ADSC byagaragaje ko TGF-β1 itera fosifora ya mTOR / S6RP / eIF4E.Hamwe na hamwe, ibyavuye muri ubu bushakashatsi byerekana ko umusaruro wa ERK ushingiye kuri TGF-β1 ugira uruhare runini mu gukwirakwiza soya peptide iterwa no gukwirakwiza ADSCs mu bihe bidafite serumu. Copyright © 2012 Elsevier Inc. Uburenganzira bwose burasubitswe.
