Ibicuruzwa

Kuvura ingirangingo z’inyamabere hamwe n’imiti ya chimiotherapeutique bishobora kuviramo guhungabana kwa pisine nucleotide.Gukurikirana ibyo byangiritse mu ngirabuzimafatizo zifite ibibyimba biva mu bantu ni ingirakamaro mu gusuzuma ingaruka zo kuvura imiti no gusobanukirwa neza n’uburyo imikorere y’ibiyobyabwenge.Muri ubu bushakashatsi, ibyiciro bitatu byimiti ya chimiotherapeutique hamwe nuburyo butandukanye bwibikorwa byakoreshejwe mugutezimbere ingirabuzimafatizo zivura imiti.Isesengura rya LC rishingiye kuri metabolomics isesengura nucleotide mu tugari twitsinda rishinzwe kugenzura hamwe nitsinda rivura ibiyobyabwenge ryakozwe.Uburyo butandukanye bwo gutunganya amakuru bwahurijwe hamwe kugirango hamenyekane ibimenyetso bya biomarkers bifitanye isano nigikorwa cyibiyobyabwenge, harimo gusesengura inzira imwe itandukanye, isesengura ryibanze ryibanze, hamwe niyakira ikora iranga umurongo.Igishimishije, selile yibibyimba byombi bigenzura hamwe nitsinda rivura ibiyobyabwenge birashobora gutandukana, kandi impinduka nyinshi zamenyekanye nka potentia l biomarkers, nka ATP, GMP, na UDP kubakoresha antimetabolite, ATP, GMP, na CTP kubintu byangiza ADN, kimwe na GMP, ATP, UDP, na GDP kubikoresho bya mitoto.Ibindi byemezwa bya biomarkers byakozwe hakoreshejwe imashini ikora iranga umurongo.Urebye agace kabo gahuye nu murongo, kari hejuru ya 0.9, dushobora kwemeza ko GMP na ATP aribwo buryo bwiza bwo kwerekana ibimenyetso byangiza imiti yangiza ADN, ndetse na GMP, ATP, na UDP kubindi byiciro bibiri byibiyobyabwenge.Ubu buryo buke bwa nucleotide ntibushobora gutandukanya uburyo bwimiti icyenda, ariko butanga ibimenyetso byibanze byerekana uruhare rwa farumasi-miti mu iterambere ry’imiti byibuze.