Ibicuruzwa

Gukomeretsa umwijima biterwa nibiyobyabwenge nimwe mumpamvu nyamukuru itera ibiyobyabwenge.Ubushobozi bwo guhanura ingaruka zumwijima wabakandida ibiyobyabwenge bivuye mumiterere yimiti yabo ningirakamaro kugirango bafashe kuyobora imishinga yo kuvumbura imiti igerageza imiti itekanye.Muri ubu bushakashatsi, twakusanyije amakuru agizwe n’ibice 951 bivugwa ko bitanga ingaruka zitandukanye mu mwijima mu moko atandukanye, agizwe n'abantu, imbeba, na nonrodents.Ingaruka z'umwijima kuri aya makuru yashyizweho zabonetse nka metadata yemeza, ikomoka ku bisobanuro bya MEDLINE ikoresheje uburyo budasanzwe bwo gukoresha amagambo n'indimi n'amategeko ya ontologiya.Twasesenguye aya makuru yashyizweho dukoresheje uburyo busanzwe bwa cheminformatics kandi twakemuye ibibazo byinshi bijyanye n’ubwoko butandukanye bw’ingaruka z’umwijima, imiti y’imiti y’ingaruka z’umwijima ku bantu, no guhanura niba uruganda runaka rushobora gutera umwijima abantu.Twasanze guhuza ingaruka zumwijima byari bike (ca 39-44%) hagati yubwoko butandukanye, bigatuma bishoboka ko ubwoko bwihariye bushobora guterwa nibintu byihariye biranga imiterere yimiti.Ibicuruzwa byakusanyirijwe hamwe n’imiti yabyo, kandi ibice bisa byasuzumwe kugirango harebwe isano iri hagati y’ubwoko bw’umwijima.Mu bihe byinshi, imyirondoro isa yagaragaye kubanyamuryango ba cluster imwe, ariko ibice bimwe byagaragaye nkibisohoka.Abasohotse bari ingingo yibanze yo kuvugurura kuva MEDLINE kimwe nandi makuru yatanzwe.Rimwe na rimwe wasangaga hagaragazwa ubundi buryo bw’ibinyabuzima, bujyanye n’ibiteganijwe hashingiwe ku miti ihuriweho n’imiti.Ibivugwa byahinduwe kandi kuri binary annotations yimiti yibanze (urugero, ingaruka zumwijima vs nta ngaruka zumwijima), kandi ibyakozwe muburyo bwa binarike yububiko-ibikorwa (QSAR) byakozwe kugirango hamenyekane niba uruganda ruteganijwe kubyara ingaruka zumwijima mubantu.Nuburyo bugaragara t butandukanye bwamakuru, moderi yerekanye imbaraga nziza zo guhanura zisuzumwa ninshuro 5 zambukiranya imipaka.Imbaraga zo guhanura zo hanze ya binary QSAR yongeye gushimangirwa no gukoresha ibice byagaruwe cyangwa byizwe nyuma yicyitegererezo.Dukurikije ubumenyi dufite, ubu ni bwo bushakashatsi bwambere bwo guhanura uburozi bw’imiti bwakoresheje uburyo bwa QSAR bwo kwerekana hamwe n’ubundi buryo bwa cheminformatics ku makuru yo kwitegereza yakozwe hakoreshejwe uburyo bwo gucukura inyandiko zikoresha mu buryo bworoshye hamwe n’intoki nkeya, byugurura amahirwe mashya yo kubyara no kwerekana imiterere y’uburozi bw’imiti. amakuru.