Amagare abiri ya isomeric [4.1.0] heptane igereranya ya glycosidase inhibitor galacto-validamine, (1R *, 2S, 3S, 4S, 5S, 6S *) - 5-amino-1- (hydroxymethyl) bicyclo [4.1.0] heptane -2,3,4-triol, yashizwemo intambwe 13 kuva 2,3,4,6-tetra-O-benzyl-D-galactose.Ibikorwa byo kubuza amine abiri yabujijwe guhinduka, hamwe na acetamide ihuye nayo, byapimwe na enzymes zubucuruzi za alpha-galactosidase ziva mubishyimbo bya kawa na E. coli.Igikorwa cyumuryango wa glycosyl hydrolase enzyme ya GH27 (ibishyimbo bya kawa) cyabujijwe guhatanwa na 1R, 6S-amine (7), imikoranire ihuza yaranzwe na K (i) agaciro ka 0.541 microM.GH36 E. coli alpha-galactosidase yerekanye imikoranire idakomeye ihuza 1R, 6S-amine (IC (50) = 80 microM).Diastereomeric 1S, 6R-amine (9) ihambiriye intege nke za galactosidase, (ibishyimbo bya kawa, IC (50) = 286 microM) na (E. coli, IC (50) = 2,46 mM).
