Ibicuruzwa

Methyl 1,2,3,4-tetra-O-acetyl-β-D-glucuronate yakoreshejwe mu bushakashatsi bwo gusuzuma igishushanyo mbonera hamwe na synthesis ya glucuronide ikomoka ku mazi ikomoka kuri camptothecine ya kanseri prodrμg monotherapy hamwe na enzyme prodrμg ubuvuzi.Yifashishijwe kandi mu bushakashatsi bwo gukora ubushakashatsi ku ruhare n’uruhare rwa glycosylthio heterocycle muri chimie ya karubone.

Synthesis yibikomoka kuri acide pentopyranic

N4-Benzoylcytosine 1- (methyl 2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate) yabonetse hamwe n'umusaruro wa 70% na glycosylation ya trimethylsilyl ikomoka kuri N4-benzoylcytosine hamwe na methyl 1,2 , 3,4-tetra-O-acetyl-β-D-glucopyranuronate imbere yibintu bitatu bihwanye na SnCl4 nkumukozi uhuza.Cytosine 1- (β-D-glucopyranosiduronamide) (IV) - amide ya aside pentopyranic - yashizwe mu musaruro ugereranyije na ammonolysis ya nucleoside (I).