Ibicuruzwa

Ifumbire ya 2 - [(2R) -2-hydroxy-3 - {[4- molekile kama hamwe nibishobora gukoreshwa mubijyanye na farumasi na chimie yubuvuzi.Kubaho kwingingo ya isoindole byerekana ko iyi nteruro ifite ibintu bimwe na bimwe byubatswe bifitanye isano na biologiya kandi byabonetse muri molekile ya bioactive.Ibikomoka kuri Isoindole byavuzwe ko byerekana ibikorwa byinshi bya farumasi, birimo anti-inflammatory, antitumor, na mikorobe. 2-hydroxy-3 - {[4- (3-oxomorpholin-4-yl) fenyl] amino} propyl itsinda muri uru ruganda rurimo hydroxyl groupe (OH) ifatanye numurongo wa karubone eshatu, igize umugongo wiyi myitwarire.Irimo kandi itsinda rya fenyl ryasimbujwe na morpholinone.Morpholine yakoreshejwe cyane muri chimie yubuvuzi bitewe nubushobozi bwayo bwo guhura nintego zitandukanye z’ibinyabuzima kandi yashyizwe mu biyobyabwenge byinshi bifite ibikorwa bitandukanye. Kuba hari itsinda rya karubone (C = O) ryifatanije n’intangangore ya isoindole byerekana ko uru ruganda rushobora gira ubushobozi bwo gukora nka ligand cyangwa modulator kubintu byihariye bya molekuline mumubiri.Ibicuruzwa bishingiye kuri karubone byakoreshejwe mu kuvumbura ibiyobyabwenge kugira ngo bisabane na enzymes, reseptors, cyangwa proteyine zigira uruhare mu nzira zitandukanye z’indwara.Nyamara, nta makuru arambuye yerekeye ibikorwa by’ibinyabuzima by’uru ruganda cyangwa intego zihariye, biragoye gutanga ibisobanuro birambuye kuri yo ikoreshwa.Ubundi bushakashatsi nubushakashatsi byasabwa kugirango umenye neza imiti ya farumasi.Mu gusoza, ibice 2 - [(2R) -2-hydroxy-3 - {[4- (3-oxomorpholin-4-yl) fenyl] amino} propyl ] -1H-isoindole-1,3 (2H) -dione, hamwe na isoindole yibanze hamwe nitsinda ryimikorere, ifite ibishoboka mubijyanye na farumasi na chimie miti.Imikoreshereze yihariye nuburyo bwibikorwa byakenera gushakishwa cyane binyuze mubushakashatsi nubushakashatsi.