Ibicuruzwa

(S) - (2-Chloro-5-iodofeni) (4- iterambere.Bimwe mubikorwa byingenzi bya CF3-112 ni nka kinase inhibitor.Kinase ni enzymes zigenga imikorere itandukanye ya selile mumubiri, harimo gukura kwingirabuzimafatizo, kugabana, no gutumanaho.Kugabanya kinase akenshi bifitanye isano n'indwara nka kanseri n'indwara ya autoimmune.CF3-112 byagaragaye ko igaragaza ibikorwa bikomeye byo guhagarika kurwanya kinase zimwe na zimwe, bigatuma iba umukandida utanga ikizere cyo guteza imbere imiti igamije. By'umwihariko, CF3-112 yerekanye ibikorwa byo kubuza kurwanya Aurora kinase, bigira uruhare runini mu kugabana kandi bakunze guhangayikishwa cyane na selile.Muguhitamo guhitamo no guhagarika izo kinase, CF3-112 irashobora gufasha guhagarika ikwirakwizwa ryihuse ryingirangingo za kanseri kandi birashobora gutanga inyungu zo kuvura.Ikindi kandi, CF3-112 yerekanye ibikorwa byibasiye izindi kinase nka FLT3 na JAK2, zifitanye isano na hematologiya. malignancies nka acute myeloid leukemia (AML) na myeloproliferative neoplasms.Guhagarika izo kinase hamwe na CF3-112 bifite ubushobozi bwo guhungabanya inzira zerekana ibimenyetso bitera gukura no kubaho kwingirangingo za kanseri, bitanga uburyo bushya bwo kuvura izo ndwara. Usibye ibikorwa byayo byo guhagarika kinase, CF3-112 irashobora kandi kugira anti -ingaruka zo gutwika.Gutwika ni igisubizo cyibinyabuzima kigira uruhare runini mu ndwara nyinshi, harimo indwara ziterwa na autoimmune hamwe nindwara zidakira.CF3-112 yerekanye amasezerano nkumubuza inzira zimwe na zimwe zitera umuriro, birashoboka gutanga uburyo bwo kuvura bwo gucunga ibi bihe.Mu gihe CF3-112 ifite imbaraga nyinshi, birakwiye ko tumenya ko hakenewe ubundi bushakashatsi niterambere kugirango dusobanukirwe neza imikorere yabyo, umutekano Umwirondoro, na Porogaramu nziza.Kimwe nibindi byose, ibizamini bikomeye hamwe nubushakashatsi bwibanze burakenewe mbere yuko bitera imbere mubigeragezo byamavuriro byabantu.Mu gusoza, CF3-112 ni uruganda rufite imbaraga zikomeye mubijyanye na chimie miti.Igikorwa cyayo cyo kubuza kinase, cyane cyane kurwanya Aurora kinase, FLT3, na JAK2, kivuga ko gishobora kuba umukandida w’iterambere ry’imiti igamije kurwanya kanseri na malariya mbi.Imiti irwanya inflammatory irerekana kandi uburyo bushobora gukoreshwa mugukemura ibibazo bya autoimmune hamwe nibihe bidakira.Nyamara, ubushakashatsi buracyakenewe kugirango ufungure ubushobozi bwuzuye bwo kuvura no gusuzuma umutekano wabwo ningirakamaro.