Ibicuruzwa

Rosuvastatin Hagati ya ZD9, izwi kandi nka Z-4- (4-Fluorophenyl) -6-Isopropyl-2 - hagati muri synthesis yimiti igabanya cholesterol Rosuvastatin.Hagati aho igira uruhare runini mukubyara Rosuvastatin, iri mubyiciro byibiyobyabwenge bizwi nka statin.ZD9 ikora nkibibanza bibanziriza synthèse ya Rosuvastatin.Mugihe cyo gukora, ZD9 ihindura imiti itandukanye kugirango itange umusaruro wanyuma, Rosuvastatin.Iyi synthèse ikubiyemo guhuza amatsinda yinyongera akora kuri molekile ya ZD9, bikavamo ihinduka ryimiti ikora imiti, Rosuvastatin.Rosuvastatin ikoreshwa cyane mukuvura hypercholesterolemia, indwara irangwa na cholesterol nyinshi mumaraso.Ikora mukubuza enzyme HMG-CoA reductase, igira uruhare runini muguhindura cholesterol mumubiri.Mugabanye umusaruro wa cholesterol, Rosuvastatin ifasha kugabanya urugero rwa cholesterol muri rusange, harimo na cholesterol ya lipoproteine ​​(LDL) yuzuye ubukana, bakunze kwita cholesterol "mbi". Nkurwego ruciriritse, ZD9 yemeza ko synthesis ya Rosuvastatin ikomeza kugenzurwa n'uburyo bunoze.Ikora nk'inyubako yubaka ihura nuruhererekane rwimiti, biganisha ku gushiraho imiyoboro yihariye hamwe nitsinda ryimikorere ikenewe mubikorwa bya farumasi ya Rosuvastatin. Synthesis ya Rosuvastatin ni inzira igoye, kandi buri gihe, harimo na ZD9, ni ngombwa mugukurikirana gushiraho neza ibicuruzwa byanyuma.Hatabayeho ZD9, synthesis ya Rosuvastatin ntabwo byashoboka, bikabangamira umusaruro wiyi miti yingenzi igabanya cholesterol.Mu ncamake, Rosuvastatin Intermediates ZD9 ikora nkigihe cyingenzi muguhuza imiti ikoreshwa cyane ya cholesterol igabanya, Rosuvastatin.Ikora nk'inyubako ihindura imiti kugirango amaherezo itange ibikoresho bikora bya farumasi.Mugira uruhare runini mubikorwa byo kubyaza umusaruro, ZD9 igira uruhare mu kuboneka imiti ikomeye yo kuvura urugero rwa cholesterol nyinshi ku barwayi.