Ibicuruzwa

5- (Bromomethyl) -4- (4-fluorophenyl) -6-isopropyl-2-Uru ruganda ruzwiho imiterere itandukanye hamwe nubushobozi rufite mugutezimbere molekile zidasanzwe nibiyobyabwenge bitewe nuburyo bwihariye hamwe nitsinda ryitwara neza.Mu nganda zimiti, uru ruganda rushobora kuba ibikoresho byingenzi byo gutangiza cyangwa hagati muguhuza imiti itandukanye. ibiyobyabwenge.Kubaho kwa atome ya bromine, atom ya fluor, itsinda rya isopropyl, hamwe nimpeta ya pyrimidine bituma iba inyubako ishimishije yo gukora molekile nshya ifite imitungo yifuza.Abashinzwe imiti n’abashakashatsi mu by'imiti barashobora guhindura no gukora iki kigo kugirango bamenyekanishe imikorere yihariye cyangwa imiterere yimiterere ifitiye akamaro ibikorwa byibiyobyabwenge cyangwa imiti ya farumasi yongerewe imbaraga.Ikindi kandi, kuba hariho amatsinda ya methyl na methylsulfonyl murirwo ruganda bituma agira akamaro muri synthesis.Itsinda rya methylsulfonyl rishobora guhura nuburyo butandukanye, nko kwimura nucleophilique, kurandura, cyangwa okiside, bigatuma habaho kwinjiza amatsinda atandukanye muri molekile yagenewe.Ubu buryo butandukanye bufite agaciro ko gukora ibinyabuzima bigoye muri laboratoire. Byongeye kandi, imiterere yikigo ituma ishobora kuba ingirakamaro mubushakashatsi bwubushakashatsi.Atome ya fluor hamwe nibindi bisimburanya bishobora kugira uruhare mubintu byihariye bigize umubiri cyangwa imiti, bigatuma biba byiza gukora iperereza kubintu bimwe na bimwe cyangwa nkibisobanuro bifatika kubushakashatsi bugereranya.Abashakashatsi bakunze gukoresha ibice nkibi kugirango basobanukirwe nubuzima bwibinyabuzima, biga kinetics reaction, batezimbere uburyo bushya bwogukora, cyangwa kuzamura imikorere yinganda zihari.Ni ngombwa kumenya ko imikoreshereze yihariye nibishobora gukoreshwa 5- (Bromomethyl) -4- ( 4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidine irashobora gutandukana bitewe nubushakashatsi bwihariye cyangwa inganda.Ibikoresho bishobora gukoreshwa birenze ibyo twavuze haruguru, kandi akamaro kayo birashobora gushakishwa naba chimiste, abahanga mu bya farumasi, abahanga mu binyabuzima, n’abandi bahanga bagize uruhare mu kuvumbura ibiyobyabwenge, siyanse y’ibikoresho, cyangwa ubushakashatsi bwa molekile. Muri make, 5- (Bromomethyl) -4 - (4-fluorophenyl) -6-isopropyl-2-Imiterere yihariye hamwe nitsinda ryitwara neza bituma iba inyubako ishimishije yo guhuza molekile nshya yibiyobyabwenge no gukora iperereza kumiti itandukanye.Ihuriro rishobora gukoreshwa ni ryagutse, kandi gukomeza gushakisha imiterere yaryo birashobora gutanga inzira yiterambere mubice byinshi bya siyansi.