Ibicuruzwa

Twakoze ubushakashatsi ku gutuza kumubiri kwa amorphous curcumin no gukwirakwiza uruhare rwa curcumin-polymer intermolecular imikoranire mugutinda kristu.Curcumin nicyitegererezo gishimishije cyingirakamaro kuko ikora imigozi ya hydrogène ya intra na intermolecular muri kristu.Hakozwe iperereza ku buryo butandukanye bwa amorphous dispersion polymers;poly (vinylpyrrolidone), Eudragit E100, carboxymethyl selulose acetate butyrate, hydroxypropyl methyl selulose (HPMC) hamwe na HPMC-acetate.Hagati ya infragre ya spekitroscopi yakoreshejwe mu kumenya no kugereranya urugero rwa curcumin-polymer.Ihungabana ryumubiri mubihe bitandukanye by ibidukikije byakurikiranwe nifu ya X-ray itandukanya.Imiti ya Curcumin itunganijwe yakurikiranwe na UV-Vis spectroscopy.Kwigunga kwa amorphous curcumin ihamye byari bigoye mugihe habuze polymers.Polymers yerekanye ko ari ingirakamaro ya curcumin kristallisation inhibitor ituma habaho umusaruro ukabije wa amorphous;icyakora, polymers yerekanaga ubushobozi butandukanye cyane bwo kubuza kristu mugihe cyo kubika igihe kirekire.Curcumin intramolecular hydrogen ihuza yagabanije urugero rwa hydrogène ihuza na polymers;kubwibyo polymers nyinshi ntabwo zari nziza cyane zo guhagarika ibintu.Muri rusange, polymers byagaragaye ko ari inzitizi za kristu, ariko kubuza byari bike kubera guhuza hydrogène yo mu bwoko bwa hydrocène ihuza curcumin, bigatuma igabanuka ryubushobozi bwa polymers bwo gukorana kurwego rwa molekile.