N, N'-Methylenebisacrylamide Cas: 110-26-9 98% Ifu yera
| Umubare wa Cataloge | XD90231 |
| izina RY'IGICURUZWA | N, N'-Methylenebisacrylamide |
| URUBANZA | 110-26-9 |
| Inzira ya molekulari | C7H10N2O2 |
| Uburemere bwa molekile | 154.1665 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
| Amategeko agenga ibiciro | 29241900 |
Kugaragaza ibicuruzwa
| Suzuma | > 98% |
| Amazi adashonga | <0.5% |
| Kugaragara | Ifu yera |
| Sulfate idasanzwe | <0.5% |
| Kubushakashatsi ukoreshe gusa, ntabwo ari ugukoresha abantu | gukoresha ubushakashatsi gusa, ntabwo ari ugukoresha abantu |
Uruhare rukomeye rwa fibroblast ziterwa na kanseri (TAF) mu gutera kanseri ubu ruragaragara muri kanseri y'ibihaha itari ntoya (NSCLC).Nyamara, uburyo bwo kuvura TAF bugarukira kubera kutumva neza uburyo bwihariye bwihariye bushingiye ku kwegeranya kwabo.Hano, ubukanishi (ni ukuvuga matrix rigidity) hamwe na mitogenic ya elegitoronike ituma ikusanyirizo rya TAF riva muburyo bukomeye bwa NSCLC: adenocarcinoma (ADC) na kanseri y'udukoko twa kanseri (SCC).Fibroblast yari ifite umuco kuri substrata yakozwe kugirango yerekane ubukana busanzwe cyangwa ibibyimba bisa na serumu zitandukanye, kandi uburyo bukomeye bwo kugenzura bwasobanuwe.Mugucunga fibroblast iva mubice bidafite ingufu, matrix ikomera yonyine yongereye kwirundanya kwa fibroblast, kandi iyi mikorere yubukanishi yari yiganje cyangwa igereranwa nimpamvu zikura zishonga zigera kuri 0.5% serumu.Ibimenyetso bitera imbaraga za matrix byatewe na β1 integrin mehano-sensing binyuze muri FAK (pY397), kandi byari bifitanye isano no kuzamuka kwa posttranscription nyuma yo kwiyongera β1 integrin imvugo.Inzira ya nyuma ya mashini-igenzura nayo yagaragaye muri TAFs ariko muburyo bwihariye, kubera ko SCC-TAFs yerekanaga FAK (pY397), imvugo β1, na ERK1 / 2 (pT202 / Y204) kuruta ADC-TAFs.Byongeye kandi, gukomera kwa matrix byatumye habaho gukusanya TAF muri SCC-TAFs (> 50%) ugereranije na ADC-TAFs (10% -20%).Ibinyuranye, SCC-TAFs ahanini wasangaga serumu itemewe, mugihe ADC-TAFs yashubije serumu nyinshi gusa.Ibyavuye mu bushakashatsi bitanga ibimenyetso byambere byerekana uburyo bwihariye bwo gukusanya NSCLC-TAF.Byongeye kandi, aya makuru ashyigikira ko imiti igamije kugarura ibihaha bisanzwe hamwe na / cyangwa β1 igenamigambi rishingiye ku mashini rishobora kuba ingirakamaro kuri SCC-TAFs, mu gihe kubuza ibimenyetso byerekana imikurire y’ibimenyetso bishobora kuba ingirakamaro kuri ADC-TAF. Ubu bushakashatsi bugaragaza uburyo butandukanye bushingiyeho. kwirundanya bidasanzwe kwa fibroblast ifasha ibibyimba muburyo bubiri bwingenzi bwa kanseri yibihaha, ibyo bizafasha mugutezimbere imiti yihariye irwanya izo selile.
