5-Sulfosalicylic acide dihydrate Cas: 5965-83-3 Cristal yera-yera
| Umubare wa Cataloge | XD90230 |
| izina RY'IGICURUZWA | 5-Sulfosalicylic aside dihydrate |
| URUBANZA | 5965-83-3 |
| Inzira ya molekulari | C7H10O8S |
| Uburemere bwa molekile | 254.215 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 29182900 |
Kugaragaza ibicuruzwa
| Sulfate | 5.5% |
| Ubushuhe | 22% max |
| Kugaragara | Umweru kugeza kuri cyera |
| Acide yose | 99 - 104% |
| Suzuma | 99% |
Polycasiyo ishakishwa nkabatwara gutanga acide nucleic acide.Polycations ni farumasi isanzwe ifite umurimo wonyine wo gutanga imizigo ivura.Ubu bushakashatsi buvuga ko synthesis ya polycation yo kwikuramo (DSS-BEN) ishingiye ku muti wa polyamine analogue N (1), N (11) -bisethylnorspermine (BENSpm).Polycation yagenewe gukora muburyo bubiri bwo gutwara gene hamwe na prodrug yibasira metabolisme idakabije muri kanseri.Dukoresheje uruvange rwa NMR na HPLC, turemeza ko polycation yo kwigwizaho-kwangirika kwangirika kwimitsi mu biyobyabwenge byababyeyi BENSpm.BENSpm yasohotse igabanya urugero rwa selile ya spermidine na spermine kandi ikagenga imisemburo ya polyamine catabolic enzymes spermine / spermidine N (1) -acetyltransferase (SSAT) na oxyde spermine (SMO).Synthesize polycations ikora polyplexes hamwe na ADN kandi ikorohereza kwandura neza.Twifashishije ubushobozi bwa BENSpm yo gukangurira selile kanseri kuri TNFα iterwa na apoptos ni, twerekana ko DSS-BEN yongera ibikorwa byo kwica selile yo kuvura TNFα.Ibyavuye mu bushakashatsi byemeza DSS-BEN nk'uburyo bubiri bwo gutanga ibintu bushobora gutanga imiti ivura no kunoza ibisubizo bivuye mu buvuzi bwa gene biturutse ku kwangirika kw'imitsi kwa DSS-BEN kugeza BENSpm ndetse n'ingaruka nziza za BENSpm kuri polyamine itemewe. metabolism muri kanseri.
