Ibicuruzwa

Ibyakirwa na P2X3 byakira ATP ni transducers zingenzi zitera nociceptive kandi zigaragazwa gusa na neuron ya sensory ganglion.Muri imbeba trigeminal ganglion (TG), imikorere ya reseptor ya P2X3 yongerewe muburyo butunguranye no guhagarika imiti ya reseptor ya natriuretic peptide reseptor-A (NPR-A), ikagaragaza uruhare rushobora kubuza peptide endogenous natriuretic peptide muri nociception yahujwe na reseptor ya P2X3.Kubura impinduka mumagambo ya poroteyine ya P2X3 yerekana ihinduka rikomeye uburyo bwo kugabanya imikorere ya reseptor ya P2X3 ntibisobanutse neza.Kugirango dusobanure neza iyi nzira mumico ya TG yimbeba, twahagaritse NPR-A ikimenyetso hamwe na siRNA ya endogenous agonist BNP, cyangwa NPR-A blokant anantin.Ni yo mpamvu, twakoze iperereza ku mpinduka zo gukwirakwiza reseptor ya P2X3 mu gice cya lipid raft membrane, uko fosifora imeze, ndetse n'imikorere yabo hamwe no gufatisha patch.Gutinda gutangira P2X3 desensisisation yari uburyo bumwe bwo kuzamura anantin iterwa no kongera ibikorwa bya P2X3.Anant mubisabwa byatumye P2X3 yakira reseptor igabanywa mugice cya lipid raft kandi igabanya P2X3 serine fosifora, ibintu bibiri bitari byuzuzanya.Inhibitori ya cGMP iterwa na protein kinase na siRNA yunganirwa na knockdown ya BNP yiganye ingaruka za anantine.Twerekanye ko muri imbeba trigeminal neurons endogenous BNP ikora kuri reseptor ya NPR-A kugirango tumenye ihungabana ryimikorere ya P2X3.Kubuza Tonic ibikorwa bya reseptor ya P2X3 by inzira ya BNP / NPR-A / PKG bibaho binyuze muburyo bubiri butandukanye: P2X3 serine fosifora na reseptor igabanywa mubice bitari raft.Ubu buryo bushya bwo kugenzura reseptor bushobora kuba intego yubushakashatsi buzaza bugamije kugabanya ibikorwa bya P2X3 byakira nabi mububabare budakira.