Ibicuruzwa

Idiopathic pulmonary fibrosis ikekwa kuba irimo gukomeretsa ibihaha biterwa nubwoko bwa ogisijeni ikora (ROS), nayo ikurikirwa na fibrosis idasanzwe.Impinduka zikura (TGF) -β1-iterwa no kwiyongera kwa myofibroblast igira uruhare runini muri fiboside idasanzwe.Duherutse kubona ko mepenzolate bromide (mepenzolate), yakoreshejwe mubuvuzi mu kuvura indwara zifata igifu, ifite imiti igabanya ROS.Muri ubu bushakashatsi, twasuzumye ingaruka za mepenzolate kuri fibrosis ya blomycine iterwa na fibrosis iterwa no gukora ibihaha mu mbeba.Uburemere bwa fibrosis yo mu bihaha bwasuzumwe no gusuzuma histopathologique no kumenya urugero rwa hydroxyproline.Ubukanishi bwibihaha (elastance) hamwe nubuhumekero [imbaraga zingirakamaro (FVC)] byasuzumwe hifashishijwe umuyaga uyobowe na mudasobwa.Imikorere y'ubuhumekero nayo yasuzumwe no gukurikirana ubwinshi bwa arterial ogisijeni (SpO2).Ubuyobozi bwa intratracheal ya mepenzolate mbere yo kuvura bleomycine bwagabanije urugero rwa fibrosis yimpaha nimpinduka mubukanishi bwibihaha bituma habaho gukira gukomeye kwa FVC na SpO2 ugereranije no kugenzura.Byongeye kandi, mepenzolate yatanze ingaruka zo kuvura niyo yatanzwe nyuma yo gukura kwa fibrosis.Ubuyobozi bwa mepenzolate bwarinze kandi indwara ya blomycine iterwa na selile yimpyiko n ibisubizo byokongoka kandi byongera umubare wa myofibroblast.Mepenzolate kandi yagabanije ibikorwa bya okiside ya NADPH hamwe na TGF-β1 ikora cyangwa yongera ibikorwa bya glutathione S-transfert (GST) imbere yo kuvura bleomycine.Ibisubizo byerekana ko ubuyobozi bwa intratracheal ya mepenzolate bwagabanije fibrosis ya blomycine iterwa na fibrosis hamwe nudukorwa twibihaha mu mbeba.Izi ngaruka zishobora guterwa ningaruka zibuza iyi miti kubikorwa bya okiside ya NADPH na TGF-β1 ningaruka zayo kuri GST.