Ibicuruzwa

Ingaruka ya acideose, ibimenyetso bya biohimiki biranga ikibyimba microen ibidukikije, ku iterambere rya kanseri na metastasis biragoye.Ingaruka ziterwa na anti-tumorigenic ziterwa na asideose zaravuzwe kandi ibidukikije bya acide byakoreshejwe mugutanga imiti yihariye, imiti yerekana amashusho, hamwe nubwoko bwa geneti mubyimba.Muri ubu bushakashatsi dukora iperereza ku gukwirakwiza no kwibanda ku ngirabuzimafatizo za B16F10 za melanoma zakozwe mu buryo bwa genoside kugira ngo zikabya gukabya pH-sensing G ya poroteyine ihujwe na reseptor GPR4.Dukoresheje umugereka wa selile twasanze GPR4 ikabije gukabya gutinda kwakagari kandi bigahindura aho biherereye bigizwe na dinamike yibanze ya fonctionnement, nko kuba fosifora yibikoresho bya fosifori byitwa kinase (FAK) na paxilline, kuri acide pH.Ibishobora kuba G-protein hamwe ninzira zerekana inzira zizo ngaruka nazo zarakozweho ubushakashatsi.Ukoresheje Rho inhibitor CT04 (C3 transferase), Rho ifitanye isano na kinase (ROCK) inhibitor Y27632 na thiazovivin, myosin yumucyo urumuri kinase (MLCK) inhibitor staurosporine cyangwa inyubako ya G12 / 13, gukwirakwiza selile byagaruwe mugihe kubuza no kubuza ibikorwa bya Gq na Gs inzira zagize bike cyangwa nta ngaruka.Muri rusange ibisubizo byacu byerekana ko binyuze muri G12 / 13 / Rho inzira yerekana inzira GPR4 ihindura imbaraga zifatika kandi bikagabanya ikwirakwizwa rya selile hamwe no guturika kwa membrane.