Doxorubicin hydrochloride CAS: 25316-40-9 99% Ifu ya Orange-umutuku Crystalline
| Umubare wa Cataloge | XD90367 |
| izina RY'IGICURUZWA | Doxorubicin hydrochloride |
| URUBANZA | 25316-40-9 |
| Inzira ya molekulari | C27H29NO11 · HCl |
| Uburemere bwa molekile | 579.98 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
| Amategeko agenga ibiciro | 29419000 |
Kugaragaza ibicuruzwa
| AmaziIbirimo | ≤ 4.0% |
| pH | 4.0-5.5 |
| Gukemura | Gukemura muri: amazi, methanol na isotonic NaCl (aq).Ubushobozi buke muri chloroform hamwe nindi mashanyarazi ikomoka. |
| Ibintu bifitanye isano | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Suzuma | 99% |
| Ibisigisigi bisigaye | Acetone n'inzoga: ≤2.5% / Acetone: ≤0.5% / Methanol: ≤500ppm |
| Ibindi Byose | ≤ 0.5% |
| Impanuka zose | ≤ 2.0% |
| Crystallinity | Yubahiriza USP |
| Kugaragara | Ifu ya orange-umutuku Crystalline |
| Kumenyekanisha | HPLC |
Abarwayi bafite P-glycoprotein na HER2 / neu (HER2) reseptor-bikabije kanseri y'ibere ikunze kugira ingaruka mbi ku mavuriro.Nyamara, nta murongo wa kanseri y'ibere uboneka mu bucuruzi ari HER2 / P-glycoprotein kabiri-nziza, igabanya ubushakashatsi muri uru rwego. Dutanga raporo ku iterambere no kuranga umurongo utarwanya ibiyobyabwenge uva mu ibere ryiza rya HER2 umurongo wa kanseri muguhindura byimazeyo cassette ya ATP-ihuza (ABC) subfamily B umunyamuryango wa 1 (ABCB1) igizwe na P-glycoproteine. imvugo.Igishimishije, ihererekanyabubasha rya ABCB1 ryanatumye habaho kwiyongera gake gene ya HER2 na proteyine.Ihererekanyabubasha rya ABCB1 ryongereye urugero rwa P-glycoproteine mu buryo bugaragara.Uburyo bukoreshwa hano mu guteza imbere uyu murongo w’akagari burakwiriye kwinjizwa byihuse, bihamye byangiza imiti ya P-glycoprotein yifashishije imiti ugereranije n’uburyo bwa tr.Ikizamini cya vitro cytotoxicity cyerekana ko uyu murongo wumurongo ufite imbaraga zo kurwanya imiti myinshi ya chimiotherapeutique.
