Ibicuruzwa

Imikorere ya molekile ya antibiotique mu kuvura umusonga wa Pseudomonas aeruginosa igabanuka bitewe no gukwirakwiza indwara ya bagiteri.Kubaho kwa sisitemu yo gutumanaho kwa bagiteri, nka kworum sensing, byatanze amahirwe mashya yo kuvura.Lactonase izimya neza acyl-homoserine ya lactone ishingiye kuri bacteri quorum sensing, yerekana ko iyi misemburo ari imiti mishya ishobora kurwanya anti-Pseudomonas ishobora gusuzumwa mu musonga. Intego yubu bushakashatsi yari iyo gusuzuma ubushobozi bwa lactonase yitwa SsoPox-I kugabanya impfu z'imbeba P. aeruginosa umusonga. Kugira ngo dusuzume SsoPox-I-yunganirwa na quorum kuzimya, twabanje gupima ibikorwa bya virusi ya virusi lasB, synthesis ya pyocianin, ibikorwa bya proteolyique byo guhagarika bagiteri no gukora biofilm ya a PAO1 imbaraga zikura imbere ya lactonase.Muburyo bukabije bwica pneumoniya ya P. aeruginosa mu mbeba, twasuzumye ingaruka zokuvurwa hakiri kare cyangwa gutinda kwa trashale hamwe na SsoPox-I ku rupfu, kubara bagiteri y'ibihaha no kwangirika kw'ibihaha. SoPox-I yagabanije ibikorwa bya virusi ya PAO1 lasB. , synthesis ya pyocianin, ibikorwa bya proteolyique no gukora biofilm.Gukoresha hakiri kare SsoPox-I byagabanije impfu z’imbeba zifite umusonga ukaze uva kuri 75% ugera kuri 20%.Kwangiza ibihaha byamateka byagabanutse cyane ariko umubare wa bagiteri wibihaha ntabwo wahinduwe nubuvuzi.Kuvurwa bitinze byajyanye no kugabanya imfu zidasanzwe.Ibisubizo byerekana ingaruka zo kurinda lactonase SsoPox-I muri pneumoniya ya P. aeruginosa kandi bikingura inzira yo gukoresha imiti izaza.