Ibicuruzwa

Kwiyongera kwa okiside mu bihe bya hyperglycemic, binyuze mu mikoranire ya AGEs na reseptor ya RAGE ndetse no gukoresha ibimenyetso bya interleukin medrated transcript transcription, byavuzwe muri kanseri.Ihinduka rya poroteyine ririmo gushakishwa ku ruhare rwabo mu iterambere no gutera imbere kwa kanseri ndetse n’ibisubizo biterwa na autoantibody kuri bo bigenda byiyongera nk’ubushakashatsi bwo kumenya indwara hakiri kare.Ubu bushakashatsi bwasesenguye impinduka muri histone H1 nyuma yo guhindurwa na methylglyoxal (MG) n'ingaruka zayo muri auto-immunopathogenez ya kanseri.Guhindura amateka ya histone yerekanaga ibyahinduwe mubisigazwa bya aromatic, yahinduye ibidukikije bya tirozine, ibidukikije byambukiranya imipaka hamwe nibisekuru bya AGEs.Yerekanye masking ya hydrophobique yamashanyarazi hamwe na hypsochromic ihinduka muri ANS fluorescence yihariye.MG yibasiwe na okiside ya histone H1 iganisha ku kwegeranya karubone.Ibipimo bya CD bya kure bya UV byerekanaga di-karubone yatewe no kongera imiterere ya alfa no kwinjiza impapuro za beta;nubushyuhe bwa termal (Tm) ubushakashatsi bwemeje ubushyuhe bwumuriro wa histone yahinduwe.Isesengura rya FTIR ryerekanye hagati ya bande ihindagurika, ibisekuruza byitsinda rya carboxyethyl hamwe na N-Cα kunyeganyega muri histone yahinduwe.Isesengura rya LCMS ryemeje ishingwa rya Nε- (carboxyethyl) lysine na microscopique electronique yerekanaga amorphous agregate.Histone yahinduwe yerekanaga koperative yahinduwe ihuza ADN.H1 yahinduwe yateje antibodiyite nyinshi za titre mu nkwavu hamwe na IgG yihariye ya sera yinkwavu yakingiwe na H1 yahinduwe yerekanye ihuza ryihariye na immunogen yayo mu isesengura rya Western Blot.IgG yitandukanije na sera y'abarwayi bafite kanseri y'ibihaha, kanseri ya prostate, kanseri y'ibere na kanseri yo mu mutwe no mu ijosi byagaragaje ko bamenyekanye neza kuri neo-epitopes kuri histone yahinduwe, byerekana ko hariho kanseri ikwirakwiza kanseri.Kubera ko raporo zerekana isano iri hagati ya AGE-RAGE axis na kanseri, glycoxidisation ya histone H1 hamwe nubudahangarwa bwayo itanga inzira zo gusobanukirwa uruhare rwa poroteyine za kirimbuzi zangiza kanseri.