Ibicuruzwa

Ubuvanganzo bugenda bugaragara bwerekana ko bispenol A (BPA), endocrine ikwirakwiza imiti ihumanya imiti, iyo ihuye n’ubuzima bwa mbere, ishobora kongera ibyago byo kwandura syndrome de metabolike.Muri ubu bushakashatsi, twasesenguye hypothesis ivuga ko guhura na BPA byanduye urubyaro rwindwara zumwijima: kwigaragaza kwa hepatike ya syndrome de metabolike, hamwe nuburyo bushoboka.Imbeba za Wistar zitwite zahawe BPA (40μg / kg / kumunsi) cyangwa ibinyabiziga mugihe cyo gutwita no konsa.Umwijima w'amateka y'umwijima, isesengura ryibinyabuzima, transcriptome, na mitochondrial imikorere yasuzumwe ku rubyaro rw'abagabo nyuma y'ibyumweru 3, 15 na 26.Mugihe cibyumweru 3 byamavuko, morphologie yumwijima idasanzwe nimikorere ntibyagaragaye mubana bavukanye BPA, ariko kugabanuka kwibikorwa byubuhumekero bwa mitochondial (MRC) (I na III) hamwe nimpinduka zikomeye mumagambo ya gene agira uruhare muri metabolism ya mitochondrial fatty metabolism yari byagaragaye ugereranije no kugenzura.Mugihe cibyumweru 15, micro-vesicular steatose mumwijima, gen-up-gulated genes zigira inzira ya lipogenezesi, kwiyongera kwa ROS no kurekura Cytc byagaragaye mubyara BPA.Noneho, ibinure byinshi mu mwijima hamwe na serumu ya ALT byagaragaye mu rubyaro rwerekanwe na BPA mu byumweru 26.Mu kwitegereza kuva kera, imikorere ya mito-iyambere ya hepatike harimo ibikorwa bya MRC, umusaruro wa ATP, ibisekuruza bya ROS hamwe na mitochondrial membrane ubushobozi bwarushijeho kuba bibi mu rubyaro rwerekanwe na BPA.Indwara ya BPA ya Perinatal igira uruhare mu iterambere rya hepatike steatose mu rubyaro rw'imbeba, zishobora gukemurwa binyuze mu mikorere mibi ya mitochondrial hepatike ndetse na metabolism ya hepatike ya lipide.