Ibicuruzwa

Gukora trombin-ikora fibrinolysis inhibitor (TAFIa) ni zinc irimo carboxypeptidase kandi ibuza cyane fibrinolysis.TAFIa inhibitori rero byitezwe gukora nka profibrinolytic agent.Muminsi ishize twatangaje igishushanyo mbonera hamwe na synthesis ya seleniyumu irimo inhibitor za TAFIa nibikorwa byabo byo kubuza.Hano twatanze raporo ya kristu yububiko bwa seleniyumu ikomeye-, sulfure-, na fosifinike irimo aside irike ibuza guhuza porcine pancreatic carboxypeptidase B (ppCPB).ppCPB ni TAFIa homologue kandi ni surrogate TAFIa yo gusesengura kristu.Imiterere ya Crystal ya ppCPB igizwe na selenium compound 1a, analogue yayo ya sulfure 2, hamwe na fosifike aside ikomoka kuri EF6265 yagenwe kuri 1.70, 2.15, na 1.90 Å.Buri inhibitor ihuza urubuga rukora rwa ppCPB muburyo busa nubwavuzwe kuri inhibitor zavuzwe mbere.Rero, mubice, seleniyumu, sulfure, na ogisijeni ya fosifinike ihuza zinc muri ppCPB.Nibikorwa bya f irst na raporo ya selenium ihuza zinc muri CPB.