Ibicuruzwa

Neuroblastoma, kanseri ya sisitemu yimpuhwe zimpuhwe, nicyo kibyimba gikunze kwibasira abana.Kwiyongera kwa MYCN no kwiyongera kwa BDNF / TrkB ni ibimenyetso biranga ibibyimba byinshi;nyamara, ˜25% gusa yibibyimba bibi byerekana ibi biranga.Kubwibyo, kumenya biomarkers yinyongera nintego zo kuvura ni ngombwa.Nkuko aminoacylase 1 (ACY1), acide amine acide deacetylase, ari imiti igabanya ibibyimba mu bihaha bito na kanseri yimpyiko, twakoze iperereza niba yaba cyangwa abandi bagize umuryango aspartoacylase (ASPA, aminoacylase 2) cyangwa aminoacylase 3 (ACY3) ishobora gutanga imikorere isa na neuroblastoma.Imvugo ya Aminoacylase yasuzumwe muri TrkB-nziza, MYCN-yongerewe imbaraga (SMS-KCNR na SK-N-BE) na TrkB-mbi, itari MYCN-yongerewe imbaraga (SK-N-AS, SK-N-SH, SH-SY5Y na SH-EP) imirongo ya selile ya neuroblastoma.Buri aminoacylase yerekanaga ahantu hatandukanye (urugero, cytosoliki ACY1, membrane ifitanye isano na ASPA na kirimbuzi ACY3).Iyo selile SK-N-SH yavuwe imiti itandukanye (urugero, aside retinoic na cAMP) mubitangazamakuru birimo serumu 10%, ACY1 niyo aminoacylase yonyine imvugo yagengwaga.ASPA yagaragaye cyane cyane muri selile SH-EP ya glial sublineage.ACY3 yagaragaye cyane mumirongo ya TrkB-nziza, MYCN-yongerewe umurongo.Aminocylase yose uko ari itatu yagaragaye muri glande isanzwe ya adrenal glande, ikibanza gikomoka kuri neuroblastoma, ariko ACY1 na ACY3 gusa ni bo bagaragaje imvugo igaragara mubyimba bya neuroblastoma.Ubucukuzi bwa bioinformatics bucukuzi bwa Kaplan-Meier bwerekanye ko imvugo ya ACY3 ihujwe no kutamenya neza, mu gihe imvugo nke ya ACY1 cyangwa ASPA ifitanye isano no kutamenya neza.Aya makuru yerekana ko imvugo ya aminoacylase itagengwa na neuroblastoma