Ibicuruzwa

Okiside ya NADPH ni umuryango wimisemburo itanga ubwoko bwa ogisijeni ikora (ROS).NOX1 (NADPH oxydease 1) na okiside ya NOX2 nisoko nyamukuru ya ROS kurukuta rwimitsi mubihe nka hypertension, hypercholesterolaemia, diyabete no gusaza, bityo rero bakaba bafite uruhare runini mubitera imbaraga za okiside, imikorere mibi ya endoteliyale hamwe no gutwika imitsi. kuvugurura arterial hamwe na aterogenezi.Muri iri Subiramo, dutezimbere igitekerezo kivuga ko ugereranije no gukoresha antioxydants isanzwe, kubuza okiside NOX1 na NOX2 nuburyo bwiza bwo kurwanya stress ya okiside.Turasobanura muri make bimwe mubisanzwe kandi bigaragara gushira NADPH oxydease inhibitor.Twongeyeho, turerekana uruhare rukomeye rwa NADPH oxydease igenga subunit, p47phox, mugikorwa cya oxydease ya NOX1 na NOX2, tunatanga inama yukuntu gusobanukirwa neza imikoranire yihariye ya molekile bishobora gutuma iterambere ryimiti isoform ihitamo kugirango ikumire cyangwa kuvura indwara zifata umutima.