Ibicuruzwa

Icyari kigamijwe muri ubu bushakashatsi kwari ukugereranya imikorere ya valproate na haloperidol mu kugabanya urwego rw’imyigaragambyo ku barwayi bahuye n’ishami ryihutirwa.Twashizeho abarwayi 80 bahangayitse cyane kugirango bakire sodium valproate (20 mg / kg) cyangwa haloperidol yo mu nda (5 mg / 1 ml).Ubukangurambaga bwapimwe kuri baseline na 30 min nyuma yo guterwa bwa mbere ukoresheje Igipimo cyo Kugenzura-Gutuza (ACES), Indwara ya Syndrome ya positif na Negative Scale-Excited Component subcale, hamwe nigipimo cyimyitwarire ya Agitated.Ku barwayi 80 bavuwe na sodium valproate, bivuze ko dosiye ya SD yari 1541.5 ± 286 mg (intera 940-2400).Ikigereranyo cyo hagati ya ACES amanota kuva kuri baseline kugeza 30 min nyuma yo guterwa ibiyobyabwenge byari 4.73 (SD = 1.93) kumatsinda ya valproate na 5.45 (SD = 2.09) kumatsinda ya haloperidol (P = 0.028).Nta tandukanyirizo ryibonekeje ryagaragaye ukurikije impinduka zingana 30 min nyuma yo gutabarwa kumunzani ibiri yinyongera.Umubare munini w'abarwayi bo mu itsinda rya haloperidol bahuye n'ikibazo cyo kwikuramo cyane (36.2%, P <0.001) n'ibimenyetso bya extrapyramidal (8.7%, P = 0.007) ugereranije n'itsinda rya valproate (2,5% yo kwikinisha cyane, nta murwayi ufite ibimenyetso bya extrapyramidal).Ibyavuye mu bushakashatsi byerekana ko mu bikorwa by’ubuvuzi byashyizweho n’ubuvuzi bwihutirwa bwo mu mutwe, valproate yo mu mitsi ikora neza nka haloperidol mu kugabanya imidugararo, hamwe n’umutekano mwiza.