Ibicuruzwa

tRNA nicyiciro cyahinduwe cyane cyubwoko bwa RNA, kandi impinduka ziboneka muri tRNA ziva mubinyabuzima byose byasuzumwe.Nuburyo butandukanye bwimiterere yimiti no kuboneka muri tRNA zitandukanye, bibera ahantu hatandukanye muri tRNA, inzira ya biosynetike yinzira ya tRNA ihindura harimo intambwe ya methylation.Ubuvumbuzi bwa vuba bwerekanye ibintu bitigeze bibaho muburyo bwo guhindura tRNA, kugenzura no gukora, byerekana ko buri nucleoside yahinduwe muri tRNA ishobora kugira imikorere yihariye.Ariko, mubimera, ubumenyi bwacu kuruhare rwo guhindura tRNA kugiti cye nuburyo bigengwa ni bike cyane.Muri ecran ya genetike yagenewe kumenya ibintu bigenga kurwanya indwara no gukora defanse muri Arabidopsis, twabonye UMUYOBOZI WA CSB3 9 (SCS9).Ibisubizo byacu byerekana SCS9 ikubiyemo tRNA methyltransferase ihuza methylation ya 2´-O-ribose yubwoko bwa tRNA bwatoranijwe muri antico don loop.Ihinduka rya SCS9 ryunganirwa na tRNA ryiyongera mugihe cyokwandura virusi ya bagiteri yitwa Pseudomonas syringae DC3000, no kutagira ihinduka nkiryo rya tRNA, nkuko bigaragara muri mutant ya scs9, byangiza cyane ubudahangarwa bw’ibimera kurwanya virusi imwe itagize ingaruka kuri aside salicylic (SA). inzira igenga ibihingwa birinda umubiri.Ibisubizo byacu bishyigikira icyitegererezo giha akamaro muguhindura tRNA zimwe na zimwe kugirango habeho igisubizo cyiza cyumudugudu muri Arabidopsis, bityo rero ikagura repertoire yibigize molekile ikenewe mugukemura neza indwara.