Ibicuruzwa

N-3 polyunsaturated fatty acide eicosapentaenoic aside (EPA) hamwe na acide docosahexaenoic (DHA) byagaragaye ko byongera imbaraga zimiti ya chimiotherapeutique mubushakashatsi bwamavuriro ku barwayi ba kanseri no gutera urupfu rwa kanseri ya apoptotique muri vitro.Kugeza ubu, EPA na DHA ntabwo bigeze bakora iperereza muri myeloma myinshi (MM).Uturemangingo twa myeloma ya muntu (L363, OPM-1, OPM-2 na U266) hamwe n’uturemangingo dusanzwe tw’amaraso mononuclear selile twagaragaye kuri EPA na DHA, kandi hapimwe ingaruka ku mikorere ya mitochondial na apoptose, gukora caspase-3, kwerekana gene n'uburozi bw'ibiyobyabwenge.Guhura na EPA na DHA byateye apoptose kandi byongera sensibilité kuri bortezomib muri selile MM.Icy'ingenzi, ntabwo byagize ingaruka ku mibereho yingirabuzimafatizo zisanzwe za muntu.Intumwa RNA imvugo yerekana ko EPA na DHA byahinduye ingirabuzimafatizo zigira uruhare munzira nyinshi zerekana ibimenyetso birimo nucleaire (NF) κB, Notch, Hedgehog, stress oxyde na Wnt.EPA na DHA bahagaritse ibikorwa bya NFκB kandi bitera apo ptose binyuze muri mitochondrial perturbation hamwe na caspase-3.Ubushakashatsi bwacu bwerekana ko EPA na DHA bitera ingaruka za cytotoxique muri MM kandi bikongerera ubukana bortezomib kandi bigasaba ko hakorwa ubushakashatsi bwimbitse bwakoreshwa muri acide n-3 polyunsaturated fatty acide mu kuvura MM