Bagiteri zo mu bwoko bwa colonike, zigaragazwa na Bacteroides thetaiotaomicron, zigira uruhare runini mu kubungabunga ubuzima bw’abantu hifashishijwe imiryango minini ya hydrolase ya glycoside (GHs) kugira ngo ikoreshe polysaccharide y’imirire ndetse na glycans nk'intungamubiri.Kwiyongera kwumuryango wa GH bigaragazwa nimiryango 23 GH92 glycosidase yashizweho na genome ya B. thetaiotaomicron.Hano twerekana ko alfa-mannosidase ikora ikoresheje uburyo bumwe bwo kwimura abantu kugirango bakoreshe N-glycans.Imiterere-yuburyo butatu ya mannosidase ebyiri za GH92 isobanura umuryango wa poroteyine zibiri aho ikigo cya catalitiki giherereye kuri interineti, gitanga aside (glutamate) nubufasha bwibanze (aspartate) kuri hydrolysis muri Ca (2 +) - uburyo bushingiye.Imiterere-yuburyo butatu ya GH92s murwego hamwe na inhibitor itanga ubushishozi muburyo bwihariye, uburyo hamwe ninzira ihuza catalizike.Ca (2+) igira uruhare runini mu gufasha kugoreka mannoside kure yubutaka bwayo (4) C (1) ihinduka ryintebe yerekeza kuri leta yinzibacyuho
