Ibicuruzwa

Acide-3 synthesis.Itsinda rya tert-butyloxycarbonyl (BOC) risanzwe rikoreshwa mukurinda by'agateganyo amatsinda akora amine mugihe cyo kwitwara gutandukanye.Muguhuza itsinda rya BOC kumurongo wa amine, reaction ya amine irahinduka, bigatuma habaho guhitamo guhitamo kumyanya yindi kuri molekile.Itsinda rya BOC rirashobora gukurwaho byoroshye mubihe byoroheje, bityo bikagaragaza imikorere yambere ya amine.Izi ngamba zo kurinda amatsinda zituma habaho guhuza neza molekile zingirakamaro, nka farumasi n’ibicuruzwa karemano.Ikindi kandi, aside-3-tert-Butoxycarbonylphenylboronic aside ikora nka reagent yingirakamaro mu gushinga karuboni-karubone.Acide ya Boronic, harimo aside ya Boc-fenylboronike, byoroshye gukora ester ya boronate iyo ikozwe na nucleophile, nka alcool cyangwa amine.Iyi ester ya boronate irashobora noneho guhinduka muburyo butandukanye, harimo Suzuki-Miyaura reaction reaction, guhuza Negishi, hamwe na Stille.Izi reaction zituma habaho molekile zingirakamaro hamwe nuburyo butandukanye bwo gusimburana hamwe nitsinda ryimikorere.Acide ya Boc-fenylboronike ni ingirakamaro cyane cyane mu kwinjiza aside ya fenylboronike muri molekile zigenewe. Byongeye kandi, aside Boc-fenylboronic igira uruhare runini muri chimie chimique.Imikorere ya aside ya boronic irashobora guhitamo gukorana na diol cyangwa boronate ester-yunvikana mumatsinda yibikorwa byibinyabuzima, bigafasha gukora igishushanyo mbonera cya boronate gishingiye kuri ferime na reseptor ligands.Acide ya Boc-fenylboronic irashobora kwinjizwa muri inibitori ya molekile ntoya, peptide, cyangwa prodrugs kugirango itange ibintu byifuzwa cyangwa byongere intego yihariye.Izi mvange zishingiye kuri boronate zerekanye amasezerano mu kuvura indwara zitandukanye, zirimo kanseri, diyabete, ndetse n’umuriro. Muri make, aside 3-tert-Butoxycarbonylphenylboronic, cyangwa aside Boc-phenylboronic, isanga uburyo butandukanye muri synthesis organique na chimie chimique.Itsinda ryayo rya BOC rikora nk'itsinda ririnda, ryemerera guhitamo guhitamo indi myanya kuri molekile.Byongeye kandi, imikorere ya acide ya boronic ituma karubone-karubone ihuza, ikorohereza synthesis ya molekile igoye.Byongeye kandi, aside Boc-fenylboronic igira uruhare runini muri chimie yubuvuzi, aho ikoreshwa mugushushanya imisemburo ya boronate ishingiye kuri boribone na reseptor ligands.Muri rusange, aside Boc-fenylboronike ni reagent ifite agaciro igira uruhare mu iterambere muri chimie synthique nubushakashatsi bwo kuvumbura ibiyobyabwenge.