Ibicuruzwa

(S) - (-) - N, N-Dimethyl-3-hydroxy-3 - -N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine iri mugutezimbere serotonine yatoranijwe ya reibake (SSRIs).SSRIs ni icyiciro cyibiyobyabwenge gikunze gukoreshwa mukuvura depression, indwara yo guhangayika, nubundi buzima bwo mumutwe.Uru ruganda rukora nkibibanziriza cyangwa gutangira ibikoresho muri synthesis ya selotonine yatoranijwe ya reuptake inhibitor, bigatuma habaho iterambere rya enantiomers yihariye hamwe nubuvuzi bunoze bwo kuvura.Mu kwinjiza (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine mu miterere y’ibiyobyabwenge, abashakashatsi barashobora guhuza imiterere y’imiti, nko kuba ifitanye isano n’abatwara serotonine, bivamo kunoza imikorere no kugabanya ingaruka. ibice.Imiterere ya chiral nuburyo butandukanye bituma iba ibikoresho byintangiriro yo kubaka molekile zigoye.Abashakashatsi barashobora gukora imbuga zitandukanye kuri molekile kugirango bamenyekanishe amatsinda atandukanye cyangwa bahindure stereochemie kugirango bashireho abakandida ibiyobyabwenge bishya.Ikindi kandi, (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine yakozweho ubushakashatsi ku buryo ishobora gukoreshwa mu kuvura indwara ya Parkinson.Ubushakashatsi bwerekanye ko uru ruganda rugaragaza ibikorwa bya dopamine agonist, bivuze ko rushobora gutera imiti ya dopamine, ikunze kwibasirwa n'indwara ya Parkinson.Irashobora kugira ubushobozi bwo kuvura mu kugabanya ibimenyetso bifitanye isano niyi ndwara ya neurodegenerative.Ni ngombwa kumenya ko (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine ikomeye. ikomatanya, kandi imikoreshereze yacyo igomba gukemurwa ubwitonzi.Abashakashatsi ninzobere bakorana nuru ruganda bakeneye kubahiriza umurongo ngenderwaho wumutekano nuburyo bwo gukemura neza no kugabanya ingaruka. Muri make, (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl ) propanamine nuruvange rwingirakamaro mugutezimbere serotonine reuptake inhibitor hamwe nizindi molekile za bioactive.Imiterere ya chiral, imiterere itandukanye, nibikorwa bishobora kuvura bigira uruhare runini mubushakashatsi bwimiti.Gukomeza kwiga no gukora ubushakashatsi kuri (S) - (-) - N, N-Dimethyl-3-hydroxy-3- (2-thienyl) propanamine irashobora kugira uruhare mugutezimbere imiti mishya hamwe nubuvuzi bushobora kuvurwa indwara zitandukanye.