Ibicuruzwa

Urusange (2S, 3R, 4S, 5S, 6R) -2- (3- (4 - ((S) -tetrahydrofuran-3-yloxy) benzyl) -4-chlorophenyl) -tetrahydro-6- (hydroxymethyl) -2 -methoxy-2H-pyran-3,4,5-triol ni molekile igoye ifite imbaraga zishobora gukoreshwa mubice bitandukanye, harimo imiti ya chimie nubuvuzi.Ikomatanyirizo ni mubyiciro bya pyranopyrans, ibyo bikaba ari cyclicique irimo impeta ya pyran yahujwe n'indi mpeta ya pyran.Kubaho kwa stereocenters nyinshi muburyo bwayo bituma iba molekile ya chiral, bivuze ko ibaho muburyo bubiri bwa enantiomeric bushobora kugira ibikorwa byibinyabuzima bitandukanye. Kimwe mubishobora gukoreshwa muriki kigo nukuvumbura ibiyobyabwenge no kwiteza imbere.Imiterere yimiterere ya molekile, nka benzyl na chlorophenyl, hamwe no kuba hari amatsinda menshi ya hydroxyl, byerekana ko ishobora kwerekana ibikorwa byibinyabuzima.Abahanga mu bya farumasi barashobora gushakisha ubushobozi bwurwo ruganda nkurwego rwambere rwo guteza imbere imiti mishya, cyane cyane izibasira indwara zirimo metabolisme ya karubone. Kubaho kwa (S) -tetrahydrofuran-3-yloxy byerekana ko uruganda rushobora kugira ubushobozi bwo gukorana hamwe na reseptor cyangwa enzymes zigira uruhare muri carbhydrate metabolism cyangwa inzira yerekana inzira.Abashakashatsi barashobora gukora iperereza kubushobozi bwayo nka inhibitor cyangwa modulator ya enzymes cyangwa reseptors zifite uruhare muriki gikorwa.Byongeye kandi, uruganda rwimiterere rushobora gutuma rushobora kuba umukandida ukwiye wo kuvura imiti ya chimique hifashishijwe uburyo bwo guhindura imiterere.Ikindi kandi, piranopeyran scafold igizwe n amatsinda menshi ya hydroxyl, akaba ari amatsinda akomeye mugushushanya ibiyobyabwenge.Amatsinda ya Hydroxyl arashobora kugira uruhare muguhuza hydrogène, bigira ingaruka kumashanyarazi, gutuza, hamwe na farumasi.Abashinzwe imiti barashobora gukoresha ayo matsinda kugirango bongere imbaraga zimbaraga, guhitamo, nibindi bikoresho bya farumasi. Imiterere yimiterere yuru ruganda irerekana kandi ko hashobora gukoreshwa mubumenyi bwa siyanse hamwe na synthesis.Itondekanya ryihariye ryamatsinda yimikorere irashobora gukoreshwa muguhuza ibice bishya kama kama nibintu byihariye cyangwa imikorere.Byongeye kandi, uruganda rushobora kuba intangiriro yo guteza imbere ibikoresho bishya, nka polymers cyangwa supramolecular structure, hamwe nibishobora gukoreshwa mubikorwa bitandukanye. Mugusoza, uruganda (2S, 3R, 4S, 5S, 6R) -2- (3- (4 - ((S) -tetrahydrofuran-3-yloxy) benzyl) -4-chlorophenil) ibiranga bituma ishobora kuba ingirakamaro muri chimie yimiti nubuvuzi, ibikoresho bya siyansi, hamwe na synthesis.Imiterere igoye hamwe nuburyo butandukanye bwamatsinda akora atanga amahirwe yo gukora ubushakashatsi mubuvumbuzi bwibiyobyabwenge, guhinduranya imisemburo, iterambere ryibikoresho, nibindi bice byubushakashatsi.