Uridine-5′-diphosphoglucuronic aside trisodium umunyu CAS: 63700-19-6 Ifu yera
| Umubare wa Cataloge | XD90382 |
| izina RY'IGICURUZWA | Uridine-5'-diphosphoglucuronic aside trisodium umunyu |
| URUBANZA | 63700-19-6 |
| Inzira ya molekulari | C15H19N2O18P2Na3 |
| Uburemere bwa molekile | 646.20 |
| Ibisobanuro birambuye | <-4 ° C. |
Kugaragaza ibicuruzwa
| Suzuma | 99% |
| Kugaragara | Ifu yera |
Ubu bushakashatsi bugamije gukora ubushakashatsi ku ngaruka z’uburozi bwa irinotecan hakoreshejwe biotransformation ya glucoaurantio-obtusin kuri aurantio-obtusin.Ubuyobozi bwa intraperitoneal (ip) bwa 100 mg / kg aurantio-obtusin bwongereye cyane uburozi bwa irinotecan, ariko ubuyobozi bwa ip bwa 100 mg / kg glucoaurantio-obtusin bwerekanye ingaruka zitari nke kuburozi bwa irinotecan.Byongeye kandi, ubwo buryo bwasobanuwe binyuze mu kumenya ubushobozi bwo kubuza glucoaurantio-obtusin na aurantio-obtusin yerekeza kuri glucuronidation metabolism ya SN-38 ifatwa nkibicuruzwa byingenzi bishinzwe uburozi bwa irinotecan.Ibisubizo byerekanye ko aurantio-obtusin yerekanye imbaraga zikomeye zo guhatanira guhangana na glucuronidation ya SN-38, ariko byagaragaye ko ubushobozi bwa glucoaurantio-obtusin bwerekeza kuri glucuronidation ya SN-38.Ibisubizo byerekanye ko biotransformation ya glucoaurantio-obtusin yerekeza kuri aurantio-obtusin yongereye uburozi bwa irinotecan binyuze mukwiyongera kwa glucuronidation ya SN-38.
