Ibicuruzwa

Trimethoprim ni lipofilique kandi idakomeye ya alkaline pyrimethamine yo mu bwoko bwa bacteriostatic agent.Ni ifu yera cyangwa hafi yera ya kristaline, idafite impumuro nziza, isharira, kandi igashonga gato muri chloroform, Ethanol cyangwa na acetone, ariko hafi yo kudashonga mumazi kandi igashonga cyane mumuti wa acide acetike glacial.Ifite antibacterial sprifike isa nibiyobyabwenge bya sulfa, ariko bifite antibacterial ikomeye.Ifite ingaruka nziza mu kuvura Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, hamwe na bagiteri zitandukanye zifite garama nziza kandi mbi.Ariko ntigikora neza kwandura Pseudomonas aeruginosa.Ubushuhe bwayo ntarengwa buri munsi ya mg / L hamwe no gukoresha byonyine byoroshye gutera indwara ya bagiteri, bityo rero ntibisanzwe bikoreshwa wenyine, kandi cyane cyane bihujwe numuti wa sulfa kugirango habeho gutegura imiti ivura indwara zinkari zinkari, amara kwandura, indwara z'ubuhumekero, dysentery, enteritis, umuriro wa tifoyide, meningite, itangazamakuru rya otitis, meningite, sepsis n'indwara zoroshye.Ifite ingaruka zo kuvura tifoyide na paratyphoide itari munsi ya ampisilline;Irashobora kandi guhuzwa n'imiti ya sulfa ikora igihe kirekire kugirango ikingire kandi ivure malariya idakira imiti ya falciparum.

Ihame ryibanze rya anti-bagiteri ya trimethoprim ni ukubangamira metabolisme ya folate muri bagiteri.Uburyo nyamukuru bwibikorwa ni uguhitamo guhitamo ibikorwa bya reductase ya dihydrofolate muri bagiteri kugirango dihydrofolate idashobora kugabanuka kuri tetrahydrofolate.Kubera ko synthesis ya aside folike ari igice cyingenzi cya acide nucleic aside biosynthesis, bityo rero ibicuruzwa birinda acide nucleic acide na proteyine synthesis.Byongeye kandi, guhuza trimethoprim (TMP) na bagiteri dihydrofolate reductase enzyme ikubye inshuro eshanu nkizikomoka kuri mammalian dihydrofolate reductase.Kwivanga hagati yacyo nibiyobyabwenge bya sulfa birashobora gutera guhagarika kabiri aside folike biosynthesis metabolism ya bagiteri kugirango habeho imbaraga zo guhuza imbaraga zizamura ibikorwa bya antibacterial yibiyobyabwenge bya sulfa, kandi bishobora guhindura ingaruka za antibacterial ingaruka ziterwa na bagiteri zigabanya imiti irwanya imiti. imirongo.Byongeye kandi, ibicuruzwa birashobora kandi kongera ingaruka za antibacterial zindi antibiyotike zitandukanye (nka tetracycline, gentamicin).