Ibicuruzwa

Telithromycin yatangijwe bwa mbere mu Budage mu rwego rwo kuvura rimwe na rimwe mu kanwa indwara zandurira mu myanya y'ubuhumekero harimo n'umusonga wanduye abaturage, ubukana bwa bagiteri bukabije bwa bronhite idakira, sinusite ikaze na tonillitis / pharyngitis.Iyi semisynthetic ikomoka kuri macrolide karemano erythromycine niyo ketolide yambere yagurishijwe, icyiciro gishya cya antibiotique kirimo C3-ketone aho kuba L-cladinose.Indwara ya antibacterial igizwe n'abantu 14 irinda intungamubiri za poroteyine za bagiteri guhuza na domaine ebyiri za 50S subunit ya ribosomes ya bagiteri.Irerekana imbaraga mubikorwa bya vitro birwanya indwara zubuhumekero zisanzwe zirimo Streptococcus pneumoniae, ibicurane bya Haemophilus, Moraxella catarrhalis na pyogène ya Streptococcus hamwe nizindi ndwara zidasanzwe.Itsinda rya 3-keto ritanga aside irike kandi rigabanya kwinjiza macrolide-lincosamide-streptogramine B irwanya kenshi na macrolide.Ibisigisigi bya C11-C12 byasimbuwe na karbamate ntibigaragara gusa kugirango byongere aho bihurira na ribosomal gusa ahubwo binagabanya guhuza uruganda kurwanya hydrolysis ya esterase no kwirinda guhangana bitewe no kurandura macrolide mu kagari na pompe ya efflux yashizwemo na gene ya mef muri virusi zimwe na zimwe. .Telithromycin ni inhibitor irushanwa hamwe na substrate ya CYP3A4.Ariko, bitandukanye na macrolide nyinshi nka troleandomycine, ntabwo ikora inzitizi ihamye CYP P-450 Fe2 + -nitrosoalkane metabolite complex ishobora kuba hepatotoxic.Uyu muti wihanganirwa kandi ukwirakwizwa neza mubice byimpyiko, ururenda rwa bronchial, toni na macandwe.Bihinduka cyane muri azulophil granules ya polymorphon nuclear neutrophile bityo bikorohereza kuyigeza kuri bagiteri ya fagocytose.