Ibicuruzwa

T-Butyl-.Azwiho ubushobozi bwo kurinda neza amatsinda ya hydroxyl no gukumira ingaruka zitifuzwa mugihe cyo guhindura imiti itandukanye.Bimwe mubintu byambere byakoreshejwe T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5- dihydroxyhexanoate iri murwego rwo guhuza ibinyabuzima bigoye.Amatsinda ya Hydroxyl arakora cyane kandi arashobora guhura nimpande zidakenewe mugihe cyo guhindura imiti.Muguhitamo kurinda ayo matsinda hamwe na T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate moiety, abahanga mu bya shimi barashobora kugenzura ibyakiriwe bakabona ibicuruzwa bifuza.Nyuma yo guhindura imiti yifuzwa irangiye, itsinda ririnda rirashobora gukurwaho byoroshye, ryemerera kugarura amatsinda yambere ya hydroxyl. Muri chimie ya karubone, T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate isanzwe ikoreshwa mukurinda molekile yisukari.Isukari irimo amatsinda menshi ya hydroxyl ashobora kwitwara hamwe na reagent, biganisha ku bicuruzwa bitifuzwa.Muguhitamo kurinda ayo matsinda ya hydroxyl hamwe na T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate, abahanga mu bya shimi barashobora gukoresha amatsinda ya hydroxyl asigaye nta nkomyi.Ibi bituma habaho synthesis yibikomoka ku isukari igoye hamwe no kwiga imikoranire ya karubone-proteyine cyangwa synthesis ya glycoconjugates. Byongeye kandi, T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5- itsinda ririnda dihydroxyhexanoate rikoreshwa mugihe cyo guhuza ibicuruzwa karemano, imiti, nibindi binyabuzima bikora.Kurinda neza no kwangiza ibintu bituma abahanga mu bya shimi bagera kuri molekile zitandukanye zubaka.Kurinda amatsinda yihariye ya hydroxyl bifasha mukugenzura inzira zifatika no kugera kuri regioselectivite cyangwa stereoselectivite yifuzwa. Mugusoza, T-butyl- (3R, 5S) -6-hydroxy 3,5-O-isopropylidene 3,5-dihydroxyhexanoate ibice byinshi bikoreshwa cyane muri chimie ngengabihe, cyane cyane mukurinda no gutesha agaciro amatsinda ya hydroxyl.Imiterere yihariye itanga uburinzi bwatoranijwe, butuma abahanga mu bya shimi bagenzura reaction no kubona ibicuruzwa bifuza.Ikoreshwa ryayo ritangirira ku guhuza ibinyabuzima bigoye kugeza kuri chimie ya karubone ndetse no gukora ibicuruzwa bisanzwe na farumasi.Ubushobozi bwimbaraga zo kurinda amatsinda ya hydroxyl neza bituma iba igikoresho ntagereranywa mubice bitandukanye byubushakashatsi bwimiti niterambere.