Ibicuruzwa

Streptomyces ambofaciens ikomatanya macrolide antibiotic spiramycin.Itsinda rya biosynetike ya gene ya spiramycine yaranzwe na S. ambofaciens.Usibye gene igenga srmR (srm22), yamenyekanye mbere (M. Geistlich et al., Mol. Microbiol. 6: 2019-2029, 1992), genes eshatu zashyizweho zashyizweho hakoreshejwe isesengura ryikurikiranya.Isesengura ryerekana imiterere ya gen hamwe nubushakashatsi bwakozwe na gene bwerekanye ko imwe gusa muri izi genes eshatu, srm40, igira uruhare runini mugutunganya biosynthesis ya spiramycin.Ihungabana rya srm22 cyangwa srm40 ryakuyeho umusaruro wa spiramycine mugihe gukabya gukabije kwabo kwongera spiramycine.Isesengura ryerekana ryakozwe na reverse transcript-PCR (RT-PCR) kuri genes zose za cluster mubwoko bwishyamba no muri srm22 (srmR) na srm40 yo gusiba.Ibisubizo bivuye mu gusesengura imvugo, hamwe n’ibyavuye mu bushakashatsi bwuzuzanya, byagaragaje ko Srm22 isabwa kugira ngo imvugo ya srm40 igaragare, Srm40 ikaba ari inzira yihariye ikora igenzura byinshi, niba atari byose, bya genoside ya spiramycine.