Ibicuruzwa

Sitagliptin ni imiti iri mu cyiciro cyibiyobyabwenge cyitwa dipeptidyl peptidase-4 (DPP-4) inhibitor.Ikoreshwa cyane cyane mugucunga diyabete yo mu bwoko bwa 2.Diyabete ibaho iyo umubiri udashoboye kugenzura neza urugero rw'isukari mu maraso, bigatuma glucose iba nyinshi mu maraso.Sitagliptine ikora ihagarika enzyme ya DPP-4, ishinzwe gusenya imisemburo ya incretin.Iyi misemburo yongera imisemburo ya insuline kandi igabanya umusaruro wa glucagon, amaherezo iganisha ku isukari nyinshi mu maraso.Muguhagarika enzyme ya DPP-4, sitagliptine ituma imisemburo ya incretin ikomeza gukora mugihe kirekire, bityo igahindura isukari yamaraso.Uburyo bwibanze bwo kuyobora sitagliptine ni umunwa, kandi burashobora gufatwa hamwe nibiryo.Igipimo cyagenwe ninzobere mu buzima kizaterwa n’impamvu z’abarwayi ku giti cyabo, nk’uburemere bwa diyabete nindi miti ikoreshwa.Ni ngombwa gukurikiza amabwiriza yatanzwe yo gufata neza witonze kandi ntuhindure urugero utabanje kubaza abashinzwe ubuzima.Sitagliptin ikunze gukoreshwa nk'umugereka w'imirire n'imyitozo ngororamubiri mu micungire ya diyabete yo mu bwoko bwa 2.Bikunze gutegekwa hamwe no guhindura imibereho hamwe nindi miti igabanya ubukana, nka metformin.Muguhuza uburyo butandukanye bwibikorwa, nka sitagliptin ya DPP-4 yo kubuza no kunoza metformin kunoza insuline, kugenzura glycemique birashobora kugerwaho. Ingaruka za sitagliptine mugucunga urugero rwisukari yamaraso byagaragaye mubigeragezo byinshi byamavuriro.Ubushakashatsi bwerekanye ko bushobora kugabanya kwiyiriza ubusa no kurya (nyuma yo kurya) glucose, bikagabanya urugero rwa gemoglobine (HbA1c), kandi bikanonosora uburyo bwo kurwanya indwara ya glycemic muri rusange. nk'ububabare bw'umutwe, indwara zo mu myanya y'ubuhumekero yo hejuru, hamwe no guhungabana mu gifu nko kugira isesemi cyangwa impiswi.Kimwe n’imiti iyo ari yo yose, ingaruka zikomeye za allergique n’ingaruka zidasanzwe ariko zikomeye zirashobora kubaho, bityo rero ni ngombwa kumenyesha bidatinze ibimenyetso bidasanzwe cyangwa bikomeye kubashinzwe ubuzima bwihuse.Mu ncamake, sitagliptin numuti ukoreshwa mugucunga diyabete yo mu bwoko bwa 2 mellitus .Nka DPP-4 inhibitor, ifasha kunoza igenzura rya glycemic mukongera ibikorwa bya hormone incretin.Iyo ikoreshejwe hamwe no guhindura imibereho hamwe nindi miti igabanya ubukana, sitagliptin irashobora kuba igikoresho cyiza mugucunga isukari yamaraso no kurwanya diyabete yo mu bwoko bwa 2.Gukurikiranira hafi no kugisha inama abatanga ubuvuzi nibyingenzi kugirango bigerweho neza.