Ibicuruzwa

Ethyl trifluoropyruvate (ETFP) nuruvange rwimiti rusanga ikoreshwa mubice bitandukanye, harimo synthesis organique, ubushakashatsi bwa farumasi, niterambere ryubuhinzi.Bikomoka kuri acide pyruvic, hamwe na atome eshatu za fluor (-F) zometse kuri karubone yegeranye nitsinda rya carboxyl hamwe nitsinda rya Ethyl (-C2H5) ryometse kuri karubone ya karubone. Kimwe mubikoresha cyane ETFP ni nkibice byinshi byubaka muri synthesis.Itsinda rya trifluoromethyl muri ETFP rifite agaciro gakomeye kuko ritanga imiti yihariye kandi yifuzwa kubintu byinjizwamo.Itsinda rya trifluoromethyl rirashobora guhindura reaction, solubilité, hamwe nibikorwa byibinyabuzima, bikabigira igikoresho cyingirakamaro kubashinzwe imiti naba chimiste ba chimique.Kubaho kwitsinda rya Ethyl ryemerera gukomeza guhindura molekile, bigafasha kwinjiza amatsinda atandukanye yimikorere no kuzamura ibice byinshi muri rusange.Etflurane, ihumeka rusange anesthetic, ni urugero rwibikorwa byakomotse kuri ETFP.Synthesis ya Etflurane ikubiyemo reaction ya ETFP hamwe na hydrogène fluoride na aside trifluoroacetic kugirango itange umusaruro wanyuma.Imyitwarire idasanzwe yitsinda rya trifluoromethyl muri ETFP ituma hashyirwaho uburyo bwo guhitamo atome ya fluor muri molekile ya Etflurane, ikayiha imiti yabwo.Itsinda rya trifluoromethyl muri ETFP rishobora kugira ingaruka zikomeye kubikorwa byibinyabuzima byibi bice.Mu kwinjiza itsinda rya trifluoromethyl muri molekile, abahanga mu bya shimi barashobora guhindura lipofilicity yikomatanya, ihindagurika ryimiterere, hamwe no guhuza imisemburo cyangwa reseptor ziboneka mubihingwa.Iri hinduka ryemerera gukora igishushanyo mbonera cyiza kandi cyatoranijwe gishobora kugenzura imikurire y’ibihingwa cyangwa gutera ibyatsi bibi bitiriwe byangiza ibihingwa byifuzwa. Usibye kuba ikoreshwa muri synthesis organique hamwe n’iterambere ry’ubuhinzi-mwimerere, ETFP nayo ikoreshwa nkibikoresho byo gutangiza synthesis. imiti itandukanye.Itsinda rya trifluoromethyl muri ETFP rishobora kuzamura imiti y’umukandida w’ibiyobyabwenge, biganisha ku kuba bioavailable iboneka, ihindagurika ry’imikorere, no guhuza poroteyine.Iri hinduka rishobora kugira ingaruka kumiti yibiyobyabwenge, guhitamo, hamwe nubushobozi bwo kuvura muri rusange.Nkindi kintu cyose kijyanye n’imiti, gufata neza no kwirinda umutekano bigomba gukurikizwa mugihe ukorana na ETFP.Ni ngombwa gukoresha ibikoresho byihariye byo kurinda umuntu, nka gants na gogles, kandi ukorera ahantu hafite umwuka mwiza.ETFP igomba kubikwa ahantu hakonje, humye, kure yubushyuhe numuriro ufunguye.Mu gusoza, Ethyl trifluoropyruvate (ETFP) nuruvange rwingirakamaro muri synthesis organique, ubushakashatsi bwimiti, niterambere ryubuhinzi.Amatsinda ya trifluoromethyl na Ethyl bituma ahinduka inyubako zinyuranye zo guhindura imiterere yimiti no kuzamura imiterere ya molekile.Kuva muri synthesis ya anesthetike kugeza iterambere ryimiti yimiti nubuvuzi, ETFP ikora nkigikoresho cyagaciro kubashinzwe imiti muburyo butandukanye bwo gukoresha.Mugukomeza gucukumbura kubyitwaramo nibiranga, abashakashatsi barashobora gufungura imikoreshereze mishya kandi bakagira uruhare mugutezimbere mubumenyi butandukanye.