Ibicuruzwa

Hyperkalemia mugihe cya sisitemu ya renin-angiotensin-aldosterone (RAAS-I) irashobora kwirinda kunywa neza.Uburyo bwo kuvura burimo sodium polystirene sulfonate potassium ihuza ibisigarira, ariko impungenge zumutekano hamwe ningaruka zirahari, harimo na nérosose ya colonike (CN).Ubundi buryo bwakorewe ubushakashatsi, ariko ibiciro-byingirakamaro ntabwo byigeze bigereranywa.Twakoze isesengura-ryingirakamaro ryibitaro by’abarwayi ≥ Imyaka 18 y'amavuko yakiriye RAAS-I idakira, hamwe n'amateka ya hyperkalemia cyangwa indwara zimpyiko zidakira, byateganijwe haba sodium polystirene sulfonate cyangwa "ibiyobyabwenge X" bihuza resin ya hyperkalemia idakira.Amakuru yakuwe mubitabo bihari.Twifashishije icyitegererezo cyo gusesengura ibyemezo hamwe na Monte Carlo isesengura ryibyiyumvo byimbitse, duhereye kubashinzwe ubuzima hamwe nigihe cyamezi 12.Ibiciro byapimwe mu madorari y'Abanyamerika.Gukora neza byapimwe mubuzima-bwahinduwe neza-imyaka (QALYs), hamwe nigipimo cyiyongera-cyiza-cyiza (ICERs) .Drug X ntishobora kugura amadolari arenga $ 10.77 kumupanga wa buri munsi kugirango ikorwe neza, kubushake-bwo kwishyura ( WTP) igipimo cyamadorari 50.000 / QALY.Ku madorari 40.00 kumunsi wa buri munsi, ibiyobyabwenge X byageze ku kigereranyo cy’ibiciro bya $ 26.088.369.00 kuri QALY yungutse.Isesengura ryuburyo bumwe bwerekanaga sodium polystirene sulfonate kugirango ibe amahitamo meza kubintu bya CN ≤ 19.9%.Intambamyi zirimo amakuru atuzuye kubyavuye hanze y’ubuvuzi no kubura amakuru ugereranya mu buryo butaziguye sodium polystirene sulfonate n’ubundi buryo bushoboka.Ibisanzwe ntibishobora kubahenze keretse igiciro kimwe na sodium polystirene sulfonate.Iri sesengura rishobora kuyobora ibyemezo byerekeranye no gufata ubundi buryo bwo kurwanya hyperkalemia idakira, kandi byerekana ko sodium polystirene sulfonate ikoreshwa nkigenzura rikomeye mugupima kwa kliniki.