Ibicuruzwa

Kugirango ushakishe imiti igabanya ubukana bwa anticancer itandukanye nimiterere nuburyo bwimikoranire ya cisplatine gakondo ikora intrastrand 1,2 GpG yongeweho, insimburangingo ya platine + ADN hamwe na ADN hamwe n’imikoranire nini idahwitse yari yarigishijwe.Byatangajwe ko imiti ya testosterone ishingiye kuri platine (II) igaragaza ibikorwa byinshi bya antikanseri.Byongeye kandi, byagaragaye kandi ko imiti ya platine ikomoka kuri testosterone ishobora gutera ADN helix gukora cyane itabishaka kandi ikunama hejuru ya platine idafite testosterone.Nyamara, uburyo bwimikoranire yibi bikoresho bya platine hamwe na ADN kurwego rwa atome ntibirasobanuka neza kugeza ubu.Mu murimo wubu, twakoresheje imitekerereze ya molekuline (MD) hamwe na ADN ihuza imbaraga zo kubara kugirango twige imiterere ya ADN igoreka testosterone- ishingiye kuri platine + ADN, itunganijwe neza ya testosterone ishingiye kuri platine + ADN hamwe na platine idashingiye kuri testosterone + ADN.Ibisubizo byerekana ko imikoranire hagati yimikorere ya platine ya testosterone yoroheje ya platine hamwe na molekile ya ADN ishobora gutera ADN igoretse ihindagurika kuruta imikoranire ya groove-isura yimikorere ya platine ikabije ya testosterone na molekile ya ADN.Iperereza ryakozwe ku muti wa platine utari testosterone ugaragaza ko habaye ihinduka ridasanzwe ry’imihindagurikire ya ADN bitewe no kubura kwa testosterone muri iyo miti.Hashingiwe ku isesengura ry’imikorere ya ADN, icyerekezo cya ADN kijyanye n’imihindagurikire y’ibice bya ADN hamwe no gusenya imigozi ya hydrogène yo gusenya ibice byombi bya ADN byaganiriweho kandi muri uyu murimo. kunoza testosterone ishingiye kuri platine + ADN yongeweho, itandukanye nimikoranire ya groove-face iterwa numuhuza ukaze muri testosterone ishingiye kuri platine.Iperereza ryubu ritanga amakuru yingirakamaro yo guhindura ADN yibasiwe na testosterone ishingiye kuri platine kurwego rwa atome.