p-hydoxybenzoic aside, monosodium Cas: 114-63-6 99% Umweru ugahinduka umuhondo cyangwa ifu ya kirisiti ya kirisiti;
| Umubare wa Cataloge | XD90141 |
| izina RY'IGICURUZWA | p-hydoxybenzoic aside, monosodium |
| URUBANZA | 114-63-6 |
| Inzira ya molekulari | C7H5O3Na |
| Uburemere bwa molekile | 160.10 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 2918290000 |
Kugaragaza ibicuruzwa
| Kugaragara | Umweru ucogora umuhondo cyangwa ifu ya kirisiti ya kirisiti |
| Assay | ≥ 99% |
| Ubucucike | 1.3750 |
| Ingingo yo gushonga | > 300 ° C (lit.) |
| Ingingo yo guteka | 336.2 ° Cat760mmHg |
| Ingingo ya Flash | 171.3 ° C. |
Kubuza anhydrases ya β-karubone (CAs, EC 4.2.1.1) bivuye mu bihumyo bitera indwara Cryptococcus neoformans (Can2) na Candida albicans (Nce103) hamwe na karubasi ya alifatique na aromatique 25.Isoforms yumuntu hCA I na II nayo yashyizwe mubushakashatsi bwo kugereranya.Aliphatic carboxylates muri rusange yari milimolar hCA I na II inhibitor hamwe na micromolar / submicromolar β-CA inhibitor.Carboxylates ya Aromatic yari micromolar inhibitor ya enzymes enye ariko zimwe murizo zagaragaje ibikorwa bya nanomolar nkeya kurwanya imisemburo ya fungal.4-Hydroxy- na 4-mikorerexy-benzoate yabujije Can2 hamwe na K (I) s ya 9.5-9.9 nM.Esteter ya methyl, hydroxamates, hydrazide na carboxamide ya bimwe muribikomokaho nabyo byagize uruhare runini mu gukumira α- na β-CAs byakorewe hano.
Parabens iri mubintu bikoreshwa cyane mukubuza gukumira mikorobe no kongera igihe cyubuzima bwibicuruzwa bitandukanye.Icyari kigamijwe muri ubu bushakashatsi kwari ukugira ngo tumenye metabolism ya parabene mu ngirangingo za kanseri y'ibere (MCF7) kuva bagaragaza ibikorwa bya estrogeneque kuri selile kandi byagaragaye mu ngingo za kanseri y'ibere.Uburozi bwa parabene kuri selile MCF7 bwagenwe hakoreshejwe MTT.Hydrolysis ya methyl-, butyl na benzyl-paraben kugeza p-hydroxybenzoic aside yasesenguwe mu ngirabuzimafatizo za MCF7 ndetse no muri homogenates.Glucuronidation na sulfoconjugation byakozwe muri MCF7 homogenates, naho parabene zasesenguwe na HPLC.Methyl-paraben yerekanwe ko idafite uburozi burenze butyl na benzyl-paraben.Parabens yari ihagaze neza muri MCF7 homogenates mugihe p-nitrophenyl acetate, ubwoko bwa substrate, yakorewe hydrolysis.MCF7 selile homogenates ntiyagaragaje ibikorwa bya glucuronidation na sulfoconjugation kuri parabens.Ihungabana ryinshi rya parabene rishobora gusobanura kwirundanya kwabo muri kanseri yamabere.
