Ibicuruzwa

Nikotinamide Riboside irashobora gukoreshwa mubushakashatsi bwibinyabuzima bwa gene circadian reprogramming transcriptome mu mwijima yerekanaga inzira ya metabolike yo gusaza mu mbeba.Yongera kandi NAD + muri cortre yubwonko kandi ikagabanya kwangirika kwubwenge muburyo bwimbeba ya transgeneque yindwara ya Alzheimer.

Nikotinamide adenine dinucleotide (NAD +) ni coenzyme ikomeye, iyo igabanijwe kuri NADH, ikora nk'igabanuka ryo gutanga electroni ya fosifori ya okiside na synthesis ya ATP muri mitochondria.NAD + ni cofactor ikomeye kuri enzymes nka sirtuins, ADP-ribosyltransferase (ARTs), na polymerase ya Poly [ADP- ribose] (PARPs) kandi ikomeza gukoreshwa niyi misemburo.Ikigereranyo cya NAD + / NADH nikintu gikomeye cyimiterere ya redox ya selire.(Verdin 2015).Kubara bimwe, NAD cyangwa NADP ifitanye isano yitabira kimwe cya kane cyibikorwa byose bya selile (Opitz Heiland 2015).Hariho ibice bitandukanye bya NAD + muri nucleus, mitochondria, na cytoplazme (Verdin 2015).
Nikotinamide riboside (NR) irashobora guhindurwa muri NAD + binyuze mu ntambwe yo hagati aho ihinduka nicotinamide mononucleotide (NMN) na NR kinase (Nrk) hanyuma ikajya kuri NAD + na NMNATs.NR isanzwe iboneka mubiribwa bimwe ariko ku bwinshi (urugero: micromolar range).Mu mateka, NR byari bigoye kubona ku bwinshi, ariko kubera iterambere ryakozwe muburyo bwa synthesis (Yang 2007), guhera muri Kamena 2013, igurishwa nk'inyongera y'ibiryo.