Ibicuruzwa

Twabanje gushiraho umuco muremure, 3-urwego rwa organoide kuva mubice byimbeba (amara, igifu, pancreas, numwijima) namara yumuntu na pancreas.Hano turasobanura ibintu bisabwa kumico ndende-3-yumuco wa selile gastric stem selile.Ikoranabuhanga rirashobora gukoreshwa mukwiga epiteliyale yatewe no kwandura Helicobacter pylori.Twabyaye organoide duhereye kuburugero rwo kubaga umubiri wa gastric.Imiterere yumuco yatejwe imbere ishingiye kuri sisitemu yimbeba gastrica na amara yumuntu.Twakoresheje microinjection kugirango twanduze organoide na H pylori.Epithelia ibisubizo byapimwe hifashishijwe micarray na numero ya polymerase yumurongo wisesengura.Ingirabuzimafatizo ya gastrica yaguwe ubuziraherezo mumico 3-yimiterere.Twateje imbere ingirabuzimafatizo ziva mu gifu zifite ubuzima bwiza, ingirabuzimafatizo imwe, cyangwa ibibyimba.Organoide yagumanye ibintu byinshi biranga imyenda yabo ishingiye ku mateka yabo, kwerekana ibimenyetso, na euploidy.Organoide iva mubice bizima byagaragaje ibimenyetso byimirongo 4 yigifu kandi yishyize hamwe muri gland na domaine.Bashobora gutegekwa kwerekana byimazeyo imirongo ya glande, cyangwa urwobo rwa gastrica, hiyongereyeho nikotinamide no gukuramo WNT.Nubwo imirongo ya gastricike yari ifite gusa ingaruka ziterwa no kwandura bagiteri, ibisekuru bya gastrica byagize ingaruka zikomeye zo gutwika.Twashyizeho uburyo bwo guha umuco organoide yumuntu.Sisitemu irashobora gukoreshwa mukwiga kwandura H pylori nizindi ndwara zo mu nda. Uburenganzira © 2015 AGA Institute.Byanditswe na Elsevier Inc. Uburenganzira bwose burasubitswe.