Ibicuruzwa

Uburemere bwo kurwanya mikorobe hamwe no kubura mikorobe nshya byongereye inyungu mu iterambere rya peptide ya mikorobe (AMPs) nk'ubuvuzi bushya.Muri ubu bushakashatsi, twasuzumye ibikorwa birwanya mikorobe ya peptide ebyiri ngufi, aribyo RRIKA na RR.Iyi peptide yerekanaga ibikorwa bikomeye bya mikorobe irwanya Staphylococcus aureus, kandi ingaruka zazo zirwanya mikorobe zongerewe cyane hiyongereyeho aside amine eshatu muri C terminus, ibyo bikaba byongera amphipathicity, hydrophobicity, hamwe na net net.Byongeye kandi, RRIKA na RR bagaragaje ingaruka zikomeye kandi zihuse ziterwa na Staphylococcus y’amavuriro n’ibiyobyabwenge, harimo na methicilline irwanya Staphylococcus aureus (MRSA), S. aureus (VISA), vancomycine irwanya S. aureus (VRSA). , linezolide irwanya S. aureus, na epidermidis ya Staphylococcus irwanya methicilline.Bitandukanye na AMP nyinshi karemano, RRIKA na RR bagumanye ibikorwa bya samuragwa imbere ya physiologique ya NaCl na MgCl2.RRIKA na RR byombi byongereye ubwicanyi bwa lysostaphin inshuro zirenga 1.000 kandi birandura burundu MRSA na VRSA mu minota 20.Byongeye kandi, peptide yatanzwe yari nziza mu kugabanya ibinyabuzima bya S. aureus na S. epidermidis ya S. ugereranije n'ibisubizo hamwe na antibiotike zisanzwe.Ibyavuye mu bushakashatsi byerekana ko ingaruka za staphylocidal ya peptide yacu zatewe no guhinduranya ururondogoro rwa bagiteri, bigatuma ibintu bya cytoplazimike biva mu rupfu.Byongeye kandi, peptide ntabwo yari uburozi kuri selile ya HeLa inshuro 4 kugeza 8 zikubye mikorobe.Ibikorwa bikomeye kandi bidafite umunyu-mikorobe ya mikorobe ya peptide irerekana umukandida ushimishije wo kuvura indwara zanduza imiti myinshi ya S. aureus.