Iodonitrotetrazolium chloride CAS: 146-68-9
| Umubare wa Cataloge | XD90473 |
| izina RY'IGICURUZWA | Iodonitrotetrazolium chloride |
| URUBANZA | 146-68-9 |
| Inzira ya molekulari | C19H13ClIN5O2 |
| Uburemere bwa molekile | 505.70 |
| Ibisobanuro birambuye | 2 kugeza 8 ° C. |
| Amategeko agenga ibiciro | 32129000 |
Kugaragaza ibicuruzwa
| Kumenyekanisha | H-NMR |
| Kugaragara | Ifu yumuhondo yijimye kugeza ifu ya orange |
| Suzuma | > 99% |
| Gukemura | Igisubizo gisobanutse |
Intungamubiri ziterwa na poroteyine 1 (IFITM1) ni umwe mu bagize umuryango wa poroteyine ya transembrane iterwa na interferon.Muri ubu bushakashatsi, twatangaje ko imvugo ya IFITM1 yazamutse muri kanseri y’umuntu (CRC) ifitanye isano rya bugufi na CRC lymph node hamwe na metastasis intera ndetse n’ubuvuzi bwateye imbere.Icyangombwa, kuzamura IFITM1 imvugo ni ibintu byigenga byerekana ubuzima bubi.Kugira ngo dukore iperereza ku mikorere ya molekile, twerekanye ko imvugo ikabije ya IFITM1 mu tugari twa CRC yateje imbere, mu gihe gukubita imvugo ya IFITM1 yabujije, kwimuka kwa selile / gutera hamwe na tumorigenicity muri vitro.Byongeye kandi, twasanze Caveolin-1 (CAV1) nk'intego yo hasi yibasiwe na IFITM1 iterwa na selile, kuko gukomanga kwa CAV1 byavanyeho siIFITM1 byahujwe no kubuza gutera selile muri selile CRC.Mubyongeyeho, mu itsinda rya CRC ry’abarwayi 229, imvugo ya IFITM1 ifitanye isano itandukanye n’imvugo ya CAV1.Ibisubizo byavugaga ko IFITM1 iteza imbere aggr yingirakamaro ya selile CRC, kandi ni ikimenyetso cyerekana ibimenyetso byerekana intego yo kuvura CRC.
