Ibicuruzwa

Gukomeretsa uruti rw'umugongo biragoye no gutakaza gutinda kwa oligodendrocytes, bikavamo demyelination idakira.Kubwibyo, ingamba zo guhinduranya kugirango zitange selile zo mu bwoko bwa oligodendrocyte no kongera urugero rwa myelination bigaragara ko zifite ishingiro zo gusana uruti rwumugongo.Ubu bushakashatsi bwakoze iperereza niba guhinduranya ingirabuzimafatizo z'umuntu (NSCs) byahinduwe mu buryo bwa genoside kugira ngo bigaragaze ibintu byandikirwa Olig2, igenzura rikomeye mu iterambere rya oligodendrocyte, bishobora guteza imbere moteri no kongera myelination mu buryo bwo gukomeretsa uruti rw'umugongo.HB1.F3 (F3 ) umurongo udahoraho wa muntu wa NSC wahinduwe hamwe na virusi ya virusi itera Olig2, igenzura rikomeye ryiterambere rya oligodendrocyte.Gukabya gukabije kwa Olig2 muri NSCs zabantu (F3.Olig2) byatumye ibikorwa bya NKX2.2 biganisha ku gutandukanya NSC mu ngirabuzimafatizo za oligodendrocyte muri vitro.Kwinjiza Olig2 byatanze ibikorwa byinshi byo gukwirakwiza, kandi umubare munini cyane wa F3.Olig2 NSCs wamenyekanye nyuma y'ibyumweru 7 nyuma yo kwimurwa mu ruti rw'umugongo rwanduye kuruta urw'ababyeyi F3 NSCs.F3.Hafi ya F3.Olig2 NSCs ifata ibintu byera byabitswe bitandukanijwe na oligodendrocytes ikuze.Guhinduranya kwa F3.Olig2 NSCs byongereye ubwinshi bwibintu byera bitarinze kandi bigabanya ubunini bwa cavity.Byongeye kandi, ibihangano bya F3.Olig2 byongereye cyane umubyimba wa myelin sheath ukikije axon mubintu byera byacitse.Hanyuma, inyamanswa zifite ibihangano bya F3.Olig2 zerekanye iterambere ryubwiza bwimikorere ya hindlimbs.Guhindura NSCs byahinduwe genetike kugirango bitandukane mumirongo ya oligodendrocytike bishobora kuba ingamba zifatika zo kunoza imikorere nyuma yihungabana ryumugongo.Ubu bushakashatsi bwerekana ko ibintu bya molekuline bigenga ibyemezo byama selile bishobora gukoreshwa kugirango habeho ubushobozi bwo kuvura bushingiye ku ngirabuzimafatizo.