Acide Folike Cas: 59-30-3 99%
| Umubare wa Cataloge | XD90435 |
| izina RY'IGICURUZWA | Acide Folike |
| URUBANZA | 59-30-3 |
| Inzira ya molekulari | C19H19N7O6 |
| Uburemere bwa molekile | 441.40 |
| Ibisobanuro birambuye | Ibidukikije |
| Amategeko agenga ibiciro | 29362900 |
Kugaragaza ibicuruzwa
| Kugaragara | Ifu y'umuhondo cyangwa orange |
| Suzuma | 99% |
| Amazi | 5.0 - 8.5% |
| Ubuziranenge bwa Chromatografique | <2.0% |
| Gukemura | Mubyukuri bidashobora gushonga mumazi hamwe na solge nyinshi.Irashonga muri acide acide no mubisubizo bya alkaline |
| Ibisigisigi kuri Ignition | <0.3% |
Muri ubu bushakashatsi, thermosensitive na folate ikora poly (Ethylene oxyde) -b-poly (okiside ya propylene) -b-poly (okiside ya Ethylene) -ploy (N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer yari synthesis.Imiterere nuburemere bwa molekuline ya copolymer byemejwe na 1H NMR, FT-IR na GPC.Ubushyuhe bwo hasi bwibisubizo (LCST) bwa copolymer bwari dogere 39.8 C. Ukoresheje doxorubicin (DOX) nkumuti wintangarugero, micrate ya folate reseptor yibasiwe na DOX yapakiwe na kopolymer.Micelles yambaye ubusa na DOX yuzuye yerekana imiterere hafi ya santimetero kandi impuzandengo yazo yari 35 nm na 50 nm.Imyitwarire yo kurekura vitro ya micelles yuzuye DOX yari ishingiye ku bushyuhe kandi igipimo cyo kurekura DOX kuri dogere 42 C (hejuru ya LCST) cyarihuse kuruta kuri dogere 37 C (munsi ya LCST).Byongeye kandi, cytotoxicity yerekana mikorobe yuzuye ya DOX na DOX yuzuye ku ngirabuzimafatizo ya kanseri y'inkondo y'umura ya HeLa hamwe n'imirongo ya kanseri y'ibihaha ya muntu A549 yerekanaga ko folate yongereye ingirabuzimafatizo za selile ziri mu ngirabuzimafatizo zigenewe cyane cyane ibyakirwa na folate.
