Ibicuruzwa

N (ε) -trifluoroacetyl-L-lysine ni inkomoko yihariye ya lysine ya aside amine, aho itsinda rya epsilon (ε) amino ririnzwe nitsinda rya trifluoroacetyl (TFA).Uru ruganda rusanga gukoreshwa mubice bitandukanye, cyane cyane muri synthesis ya peptide nubushakashatsi bwibinyabuzima. Kimwe mu gukoresha cyane N (ε) -trifluoroacetyl-L-lysine iri muri synthesis ya peptide ikomeye (SPPS).Peptide igira uruhare runini mubikorwa byinshi byibinyabuzima, kandi synthesis ikenera guteranya urukurikirane rwa aside amine.Itsinda ririnda TFA kumurwi wa epsilon amino ya lysine irinda reaction zitifuzwa mugihe cyo guhuza peptide mugihe yemerera andi acide amine gushyingiranwa kumwanya wifuzwa.Inteko ya peptide imaze kurangira, itsinda ririnda TFA rishobora gukurwaho, kandi ibisigisigi bya N (ε) -trifluoroacetyl-L-lysine birashobora kuramburwa kugirango bihuze peptide yihariye.N (ε) -trifluoroacetyl-L-lysine nayo ikoreshwa mubushakashatsi bwibinyabuzima kugirango yige imiterere ya poroteyine, imikorere, n’imikoranire.Irashobora kuba igikoresho cyo gukora iperereza ku ruhare rwibisigazwa bya lysine mu mikoranire ya poroteyine-poroteyine, imikoranire ya poroteyine na ADN, hamwe n’ibihinduka nyuma y’ubuhinduzi.Mugutangiza itsinda rya TFA, imiterere yimiti ya lysine irashobora guhindurwa, bigatuma habaho iperereza ryibikorwa byihariye byahujwe na lysine muri sisitemu y’ibinyabuzima.Ikindi kandi, N (ε) -trifluoroacetyl-L-lysine irashobora kandi gukoreshwa mugutezimbere intego uburyo bwo gutanga ibiyobyabwenge.Muguhuza imiti yihariye yo kuvura ibisigazwa bya lysine binyuze mumatsinda ya TFA, birashoboka kongera umutekano no guhitamo imiti, biganisha kumikorere myiza no kugabanya ingaruka mbi.Izi ngamba zashakishijwe mugutanga imiti igabanya ubukana, antibiyotike, nubundi buryo bwo kuvura. Usibye kuyikoresha mu buryo butaziguye, N (ε) -trifluoroacetyl-L-lysine irashobora kandi gukoreshwa nk'inyubako yo guhuza ibindi bikoresho bikora. .Imiterere yihariye ya chimique na reactivite ituma iba ikintu cyiza gitangira cyangwa kigereranya guhuza sintezike ya molekile igoye, harimo imiti, imiti y’ubuhinzi, n’ibikoresho.Nyamara, ni ngombwa gufata N (ε) -trifluoroacetyl-L-lysine witonze, gukurikiza ingamba zikwiye z'umutekano.Birasabwa gukorera muri laboratoire ihumeka neza kandi ugakoresha ibikoresho bikingira umuntu ku giti cye, nk'uturindantoki n'indorerwamo z'umutekano. Muri make, N (ε) -trifluoroacetyl-L-lysine ni inkomoko y'agaciro ya lysine isanga porogaramu zitandukanye muri peptide synthesis, ubushakashatsi bwibinyabuzima, gutanga imiti igamije, hamwe na synthesis.Ubushobozi bwayo bwo kurinda epsilon amino itsinda rya lysine ituma habaho synthesis ya peptide neza, mugihe imiterere yimiti yahinduwe ituma ubushakashatsi bwibikorwa bya lysine.Iyo ikoreshejwe neza, N (ε) -trifluoroacetyl-L-lysine yerekana ko ari igikoresho cyingirakamaro mubikorwa bitandukanye bya siyansi ninganda.