Ibicuruzwa

Kugira ngo dukore iperereza ku ruhare rw’imyuka ya okiside na / cyangwa ubumuga bwa mitochondrial mu gihe cyo gukomeretsa impyiko zikabije (AKI) mu gihe cya sepsis, twateje imbere sepsis iterwa na moderi ya vitro dukoresheje selile ya tubular epithelial selile ihura na endotoxine ya bagiteri (lipopolysaccharide, LPS).Iperereza ryatanze ibintu by'ingenzi ku isano iri hagati yo guhangayikishwa na okiside na mitochondrial imikorere yubuhumekero.Ubuvuzi bwa LPS bwatumye habaho kwiyongera mu mvugo ya synthase ya nitric oxyde ya nitric (iNOS) na NADPH oxydease 4 (NOX-4), byerekana ko cytosolike ikabije ya okiside ya nitric na anion ya superoxide, ubwoko bwibanze bwa azote (RNS) nubwoko bwa ogisijeni ikora; (ROS).Iyi leta ya okiside yasaga nkaho ihagarika mitochondrial oxyde fosifora mugabanya ibikorwa bya cytochrome c oxydease.Ingaruka zabyo, ihungabana mu bwikorezi bwa elegitoronike hamwe na proton ivoma hejuru ya mitochondrial imbere yimbere yabayeho, bituma habaho igabanuka rya mitochond rial membrane ubushobozi, kurekura ibintu bitera apoptotique no kugabanuka kwa trifosifate ya adenosine.Igishimishije, nyuma yo kwibasirwa na RNS na ROS, mitochondriya nayo yaje gukora ROS, bityo igira uruhare mu kongera imikorere mibi ya mito-iyambere.Uruhare rwa okiside mu mikorere mibi ya mitochondrial rwashimangiwe kandi n’ikoreshwa rya inhibitori ya iNOS cyangwa antioxydants irinda ibikorwa bya okiside ya cytochrome c kandi ikabuza kwanduza mitochondial.Ibi bisubizo byerekana ko AKI iterwa na sepsis idakwiye gufatwa gusa nko kunanirwa kwingufu ahubwo ikanasubizwa hamwe, harimo ibyabaye byandikirana, ibimenyetso bya ROS, ibikorwa bya mito-iyambere ndetse nicyerekezo cya metabolike nka apoptose.