Ibicuruzwa

Ibidukikije, nka macronutrient yibigize indyo, birashobora kugira ingaruka zikomeye kubibazo bya diyabete na syndrome de metabolike.Muri ubu bushakashatsi turerekana uburyo ikintu kimwe, cyoroshye cyimirire - leucine - gishobora guhindura insuline irwanya gukora mubice byinshi no murwego rwinshi rwa metabolism.Imbeba zashyizwe ku mafunguro asanzwe cyangwa menshi (HFD).Leucine y'ibiryo yikubye kabiri hiyongereyeho amazi yo kunywa.mRNA, proteyine hamwe na profili ya metabolomic yuzuye byasuzumwe mubice byingenzi bya insuline byoroshye na serumu, kandi bifitanye isano nimpinduka za glucose homeostasis hamwe na signal ya insuline.Nyuma yibyumweru 8 kuri HFD, imbeba zagize umubyibuho ukabije, umwijima wamavuta, impinduka ziterwa na tipusi ya adipose hamwe no kurwanya insuline kurwego rwa fosifori ya IRS-1, ndetse no guhindura imiterere ya metabolomic ya metabolite ya aside amine, abahuza TCA cycle, glucose na cholesterol metabolite , hamwe na aside irike mu mwijima, imitsi, ibinure na serumu.Kwikuba kabiri ibiryo bya leucine byerekana ko ibintu byinshi bidasanzwe bya metabolite kandi bigatera iterambere ryagaragaye mu kwihanganira glucose no kwerekana ibimenyetso bya insuline bidahinduye ibiryo cyangwa kongera ibiro.Kwiyongera kw'imirire y'ibiryo byanajyanye no kugabanuka kwa hepatike ya hepatike no kugabanuka k'umuriro muri tipusi ya adipose.Izi mpinduka zabaye nubwo kwiyongera kwa fosifori ya insuline iterwa na p70S6 kinase yerekana ko ibikorwa bya mTOR byongerewe imbaraga, ibintu bisanzwe bifitanye isano no kurwanya insuline.Aya makuru yerekana ko impinduka zoroheje mubintu bimwe byangiza ibidukikije / intungamubiri zishobora guhindura inzira nyinshi zo guhinduranya no kwerekana ibimenyetso kandi bigahindura syndrome ya HFD iterwa na metabolike ikora kurwego rwa sisitemu kumubiri.Aya makuru yerekana kandi ko kongera lusine yimirire bishobora gutanga umugereka mugucunga insuline ziterwa n'umubyibuho ukabije.