Ibicuruzwa

Niacin (acide nicotinic) nka mitiweli irashobora kugabanya ibyago byindwara zifata imitsi, ariko uburyo bwibikorwa byayo bikomeje kutavugwaho rumwe, kandi ntibishobora guterwa ningaruka zo guhindura lipide.Niacin iherutse kwerekanwa kunoza imikorere ya endoteliyale no kuvugurura imitsi, idashingiye ku gukosora dyslipidemiya, muburyo bwimbeba zo gukomeretsa kw'amaraso n'indwara ya metabolike.Nkibishobora kuba biosintetike ibanziriza NAD (+), niacin irashobora gutanga izo nyungu zamaraso binyuze muri NAD (+) - biterwa, sirtuin (SIRT) ibisubizo byabunzi.Ubundi, niacin irashobora gukora ikoresheje reseptor yayo, GPR109A, kugirango iteze imbere imikorere ya endoteliyale, nubwo selile endoteliyale itazwiho kwerekana iyi reseptor.Twakekereje ko niacin iteza imbere imikorere ya selile ya endoteliyale mugihe cyo guhura na lipotoxique kandi dushaka kumenya uburyo bushobora kubigiramo uruhare. ugereranije ni bike bya niacin (10 μM), cyangwa nikotinamide mononucleotide (NMN) (1 μM), NAD (+) ibanziriza.Nubwo niacin na NMN byombi byateje imbere imiyoboro ya HMVEC mugihe cyo kurenza palmitite, NMN yonyine yongereye selile NAD (+) na SIRT1.Twabonye kandi ko HMVEC igaragaza GRP109A.Gukora iyi reseptor hamwe na acifran cyangwa MK-1903 byongeye gusubiramo iterambere rya niacin ryatewe no gushinga imiyoboro ya HMVEC, mugihe GPR109A siRNA yagabanije ingaruka za niacin. +) biosynthesis na SIRT1, ariko binyuze muri niacin reseptor.