Ibicuruzwa

1. Icyari kigamijwe muri ubu bushakashatsi kwari ugutegura uburyo bworoshye bwa pharmacokinetic-pharmacodynamic (PK-PD) bushobora kuranga igihe cyuzuye-cyigihe cyo guhindura imibare ya platelet kugirango hamenyekane intangiriro nintera ya trombocytopenia, igabanya cyane imikoreshereze yimikoreshereze anticancer agent 5-fluorouracil (5-FU), mu mbeba.2. Umubare wa platel wapimwe mu mbeba nyuma yubuyobozi bwimitsi yimiti itandukanye ya 5-FU muminsi 4 kugirango ubone amakuru yo gusesengura icyitegererezo cya PK-PD.Moderi yacu ya PK-PD yari igizwe nibice bibiri bigize moderi ya PK, hamwe nibice bitatu byerekana icyitegererezo cya PD hamwe nibintu 10 byubaka PK-PD.3. Nyuma yo kuvura 5-FU, umubare wa platel wagabanutse byigihe gito kugeza kurwego rwa nadir, werekana ko wagarutse hejuru yurwego rwibanze mbere yo gukira kurwego rwibanze.Nadir platelet ibara no kwisubiramo bitandukanye nurwego rwa AUC0-∞.Icyitegererezo cya PK-PD cyarangaga neza imibare ya platelet hamwe nibipimo bya PD byagereranijwe neza.4. Ubu buryo bwa PK-PD no kwigana bushobora kwerekana igikoresho cyingenzi cyo kubara no guhanura igihe cyuzuye-cyimpinduka mu mibare y’amaraso, kandi gishobora kugira uruhare mu gushyiraho ingamba zo kuvura hamwe na 5-FU no gusuzuma ibintu bitandukanye bivura antikanseri. ibyo biragoye kubisuzuma mubantu.